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10.1038/s41467-021-25361-5 http://scihub22266oqcxt.onion/10.1038/s41467-021-25361-5 34433827!8387416!34433827     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34433827&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34433827.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2021 ; 12 (1): 5120 Nephropedia Template TP {{tp|p=34433827|t=2021. A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome |pdf=|usr=}}{{34433827}} gab.com Text A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34433827 #FOAvip COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 million deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on the human genome remain unexplored. Here, we report a high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells. Intriguingly, substantial amount of SARS-CoV-2 translation initiates at a novel translation initiation site (TIS) located in the leader sequence, termed TIS-L. Since TIS-L is included in all the genomic and subgenomic RNAs, the SARS-CoV-2 translatome may be regulated by a sophisticated interplay between TIS-L and downstream TISs. TIS-L functions as a strong translation enhancer for ORF S, and as translation suppressors for most of the other ORFs. Our global temporal atlas provides compelling insight into unique regulation of the SARS-CoV-2 translatome and helps comprehensively evaluate its impact on the human genome. Twit Text FOAVip A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34433827 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34433827 #FOAvip English Wikipedia <ref>{{Cite pmid|34433827}}</ref> A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome #MMPMID34433827 Kim D; Kim S; Park J; Chang HR; Chang J; Ahn J; Park H; Park J; Son N; Kang G; Kim J; Kim K; Park MS; Kim YK; Baek D Nat Commun 2021[Aug]; 12 (1): 5120 PMID34433827show ga COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 million deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on the human genome remain unexplored. Here, we report a high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells. Intriguingly, substantial amount of SARS-CoV-2 translation initiates at a novel translation initiation site (TIS) located in the leader sequence, termed TIS-L. Since TIS-L is included in all the genomic and subgenomic RNAs, the SARS-CoV-2 translatome may be regulated by a sophisticated interplay between TIS-L and downstream TISs. TIS-L functions as a strong translation enhancer for ORF S, and as translation suppressors for most of the other ORFs. Our global temporal atlas provides compelling insight into unique regulation of the SARS-CoV-2 translatome and helps comprehensively evaluate its impact on the human genome. |*Protein Biosynthesis[MESH] |*Transcriptome[MESH] |COVID-19/*virology[MESH] |Gene Expression Regulation, Viral[MESH] |Genome, Human[MESH] |Humans[MESH] |Open Reading Frames[MESH] |RNA, Viral/genetics/metabolism[MESH] |SARS-CoV-2/*genetics/metabolism[MESH]A high-resolution temporal atlas of the SARS-CoV-2 translatome and tra(epmc).pdf DeepDyve Pubget Overpricing