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10.1073/pnas.2111315118 http://scihub22266oqcxt.onion/10.1073/pnas.2111315118 34433692!8449354!34433692     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (37): ä Nephropedia Template TP {{tp|p=34433692|t=2021. Profound Treg perturbations correlate with COVID-19 severity |pdf=|usr=}}{{34433692}} gab.com Text Profound Treg perturbations correlate with COVID-19 severity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34433692 #FOAvip The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We hypothesized that perturbations in FoxP3(+) T regulatory cells (Treg), key enforcers of immune homeostasis, contribute to COVID-19 pathology. Cytometric and transcriptomic profiling revealed a distinct Treg phenotype in severe COVID-19 patients, with an increase in Treg proportions and intracellular levels of the lineage-defining transcription factor FoxP3, correlating with poor outcomes. These Tregs showed a distinct transcriptional signature, with overexpression of several suppressive effectors, but also proinflammatory molecules like interleukin (IL)-32, and a striking similarity to tumor-infiltrating Tregs that suppress antitumor responses. Most marked during acute severe disease, these traits persisted somewhat in convalescent patients. A screen for candidate agents revealed that IL-6 and IL-18 may individually contribute different facets of these COVID-19-linked perturbations. These results suggest that Tregs may play nefarious roles in COVID-19, by suppressing antiviral T cell responses during the severe phase of the disease, and by a direct proinflammatory role. Twit Text FOAVip Profound Treg perturbations correlate with COVID-19 severity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34433692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34433692 #FOAvip English Wikipedia <ref>{{Cite pmid|34433692}}</ref> Profound Treg perturbations correlate with COVID-19 severity #MMPMID34433692 Galvan-Pena S; Leon J; Chowdhary K; Michelson DA; Vijaykumar B; Yang L; Magnuson AM; Chen F; Manickas-Hill Z; Piechocka-Trocha A; Worrall DP; Hall KE; Ghebremichael M; Walker BD; Li JZ; Yu XG; Mathis D; Benoist C Proc Natl Acad Sci U S A 2021[Sep]; 118 (37): ä PMID34433692show ga The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We hypothesized that perturbations in FoxP3(+) T regulatory cells (Treg), key enforcers of immune homeostasis, contribute to COVID-19 pathology. Cytometric and transcriptomic profiling revealed a distinct Treg phenotype in severe COVID-19 patients, with an increase in Treg proportions and intracellular levels of the lineage-defining transcription factor FoxP3, correlating with poor outcomes. These Tregs showed a distinct transcriptional signature, with overexpression of several suppressive effectors, but also proinflammatory molecules like interleukin (IL)-32, and a striking similarity to tumor-infiltrating Tregs that suppress antitumor responses. Most marked during acute severe disease, these traits persisted somewhat in convalescent patients. A screen for candidate agents revealed that IL-6 and IL-18 may individually contribute different facets of these COVID-19-linked perturbations. These results suggest that Tregs may play nefarious roles in COVID-19, by suppressing antiviral T cell responses during the severe phase of the disease, and by a direct proinflammatory role. |Adult[MESH] |Aged[MESH] |CD4-Positive T-Lymphocytes/virology[MESH] |COVID-19/*etiology[MESH] |Female[MESH] |Forkhead Transcription Factors/genetics/metabolism[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Inflammation/metabolism/virology[MESH] |Interleukin-18/genetics/metabolism[MESH] |Interleukin-2 Receptor alpha Subunit/genetics/metabolism[MESH] |Interleukin-6/genetics/metabolism[MESH] |Lymphocytes, Tumor-Infiltrating/physiology[MESH] |Male[MESH] |Middle Aged[MESH] |Severity of Illness Index[MESH] |T-Lymphocytes, Regulatory/immunology/*physiology/virology[MESH]Profound Treg perturbations correlate with COVID-19 severity (epmc).pdf DeepDyve Pubget Overpricing