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10.1016/j.celrep.2021.109637

http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109637
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34433082!8361213!34433082
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suck abstract from ncbi


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pmid34433082      Cell+Rep 2021 ; 36 (9): 109637
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  • Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose #MMPMID34433082
  • Rhoades NS; Pinski AN; Monsibais AN; Jankeel A; Doratt BM; Cinco IR; Ibraim I; Messaoudi I
  • Cell Rep 2021[Aug]; 36 (9): 109637 PMID34433082show ga
  • Research conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and coronavirus disease 2019 (COVID-19) generally focuses on the systemic host response, especially that generated by severely ill patients, with few studies investigating the impact of acute SARS-CoV-2 at the site of infection. We show that the nasal microbiome of SARS-CoV-2-positive patients (CoV(+), n = 68) at the time of diagnosis is unique when compared to CoV(-) healthcare workers (n = 45) and CoV(-) outpatients (n = 21). This shift is marked by an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa, which is also positively associated with viral RNA load. Additionally, we observe a robust host transcriptional response in the nasal epithelia of CoV(+) patients, indicative of an antiviral innate immune response and neuronal damage. These data suggest that the inflammatory response caused by SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens in the nasal cavity that could contribute to increased incidence of secondary bacterial infections.
  • |*COVID-19/complications/immunology/microbiology[MESH]
  • |*Microbiota[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Bacteria/*classification/isolation & purification[MESH]
  • |Bacterial Infections/*microbiology[MESH]
  • |Coinfection/microbiology/virology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |DNA, Bacterial/genetics[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Inflammation[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nose/microbiology[MESH]
  • |Pseudomonas Infections/microbiology[MESH]
  • |Pseudomonas aeruginosa/isolation & purification[MESH]
  • |RNA, Ribosomal, 16S/genetics[MESH]
  • |RNA, Viral/genetics[MESH]
  • |RNA-Seq[MESH]
  • |Transcriptome[MESH]
  • |Viral Load[MESH]


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