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10.1007/s11427-021-1990-5

http://scihub22266oqcxt.onion/10.1007/s11427-021-1990-5
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34431042!8384091!34431042
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suck abstract from ncbi


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pmid34431042      Sci+China+Life+Sci 2022 ; 65 (4): 701-717
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  • Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry #MMPMID34431042
  • Zhu S; Liu Y; Zhou Z; Zhang Z; Xiao X; Liu Z; Chen A; Dong X; Tian F; Chen S; Xu Y; Wang C; Li Q; Niu X; Pan Q; Du S; Xiao J; Wang J; Wei W
  • Sci China Life Sci 2022[Apr]; 65 (4): 701-717 PMID34431042show ga
  • The outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has created a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor ACE2 is low or almost absent, suggesting the existence of alternative viral entry pathways. Here, we performed a genome-wide barcoded-CRISPRa screen to identify novel host factors that enable SARS-CoV-2 infection. Beyond known host proteins, i.e., ACE2, TMPRSS2, and NRP1, we identified multiple host components, among which LDLRAD3, TMEM30A, and CLEC4G were confirmed as functional receptors for SARS-CoV-2. All these membrane proteins bind directly to spike's N-terminal domain (NTD). Their essential and physiological roles have been confirmed in either neuron or liver cells. In particular, LDLRAD3 and CLEC4G mediate SARS-CoV-2 entry and infection in an ACE2-independent fashion. The identification of the novel receptors and entry mechanisms could advance our understanding of the multiorgan tropism of SARS-CoV-2, and may shed light on the development of COVID-19 countermeasures.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2/genetics[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics[MESH]
  • |Clustered Regularly Interspaced Short Palindromic Repeats[MESH]
  • |Humans[MESH]


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