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10.1038/s42003-021-02529-9 http://scihub22266oqcxt.onion/10.1038/s42003-021-02529-9 34429502!8385044!34429502     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 999 Nephropedia Template TP {{tp|p=34429502|t=2021. The structure of a dimeric form of SARS-CoV-2 polymerase |pdf=|usr=}}{{34429502}} gab.com Text The structure of a dimeric form of SARS-CoV-2 polymerase JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34429502 #FOAvip The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed of the catalytic subunit nsp12, two copies of subunit nsp8, and one copy of subunit nsp7. Here we report an alternative, dimeric form of the enzyme and resolve its structure at 5.5 A resolution. In this structure, the two RdRps contain only one copy of nsp8 each and dimerize via their nsp7 subunits to adopt an antiparallel arrangement. We speculate that the RdRp dimer facilitates template switching during production of sub-genomic RNAs. Twit Text FOAVip The structure of a dimeric form of SARS-CoV-2 polymerase ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34429502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34429502 #FOAvip English Wikipedia <ref>{{Cite pmid|34429502}}</ref> The structure of a dimeric form of SARS-CoV-2 polymerase #MMPMID34429502 Jochheim FA; Tegunov D; Hillen HS; Schmitzova J; Kokic G; Dienemann C; Cramer P Commun Biol 2021[Aug]; 4 (1): 999 PMID34429502show ga The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed of the catalytic subunit nsp12, two copies of subunit nsp8, and one copy of subunit nsp7. Here we report an alternative, dimeric form of the enzyme and resolve its structure at 5.5 A resolution. In this structure, the two RdRps contain only one copy of nsp8 each and dimerize via their nsp7 subunits to adopt an antiparallel arrangement. We speculate that the RdRp dimer facilitates template switching during production of sub-genomic RNAs. |Dimerization[MESH] |Humans[MESH] |RNA-Dependent RNA Polymerase/chemistry/metabolism[MESH]The structure of a dimeric form of SARS-CoV-2 polymerase (epmc).pdf DeepDyve Pubget Overpricing