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10.1016/j.bjid.2021.101606 http://scihub22266oqcxt.onion/10.1016/j.bjid.2021.101606 34428473!8367756!34428473     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34428473&cmd=llinks): Failed to open stream: HTTP request failed! 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The impact of spike mutated variants of SARS-CoV2 Alpha, Beta, Gamma, Delta, and Lambda on the efficacy of subunit recombinant vaccines |pdf=|usr=}}{{34428473}} gab.com Text The impact of spike mutated variants of SARS-CoV2 Alpha, Beta, Gamma, Delta, and Lambda on the efficacy of subunit recombinant vaccines JO: Braz J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34428473 #FOAvip Since the first described human infection with SARS-CoV-2 in December of 2019 many subunit protein vaccines have been proposed for use in humans. Subunit vaccines use one or more antigens suitable for eliciting a robust immune response. However, the major concern is the efficacy of subunit vaccines and elicited antibodies to neutralize the variants of SARS-CoV-2 like B.1.1.7 (Alpha), B.1.351 (Beta) and P1 (Gamma), B.1.617 (Delta) and C.37 (Lambda). The Spike protein (S) is a potential fragment for use as an antigen in vaccine development. This protein plays a crucial role in the first step of the infection process, as it binds to Angiotensin-Converting Enzyme 2 (ACE2) receptor and enters the host cell after binding. Immunization-induced specific antibodies against the receptor binding domain (RBD) may block and effectively prevent virus invasion. The focus of this review is the impact of spike mutated variants of SARS-CoV2 (Alpha, Beta, Gamma, Delta, and Lambda) on the efficacy of subunit recombinant vaccines. To date, a low or no significant impact on vaccine efficacy against Alpha and Delta variants has been reported. Such an impact on vaccine efficacy for Beta, Delta, Gamma, and Lambda variants may be even greater compared to the Alpha variant. Nonetheless, more comprehensive analyses are needed to assess the real impact on vaccine efficacy brought about by SARS-CoV-2 variants. Twit Text FOAVip The impact of spike mutated variants of SARS-CoV2 Alpha, Beta, Gamma, Delta, and Lambda on the efficacy of subunit recombinant vaccines ????Braz J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34428473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34428473 #FOAvip English Wikipedia <ref>{{Cite pmid|34428473}}</ref> The impact of spike mutated variants of SARS-CoV2 Alpha, Beta, Gamma, Delta, and Lambda on the efficacy of subunit recombinant vaccines #MMPMID34428473 Mohammadi M; Shayestehpour M; Mirzaei H Braz J Infect Dis 2021[Jul]; 25 (4): 101606 PMID34428473show ga Since the first described human infection with SARS-CoV-2 in December of 2019 many subunit protein vaccines have been proposed for use in humans. Subunit vaccines use one or more antigens suitable for eliciting a robust immune response. However, the major concern is the efficacy of subunit vaccines and elicited antibodies to neutralize the variants of SARS-CoV-2 like B.1.1.7 (Alpha), B.1.351 (Beta) and P1 (Gamma), B.1.617 (Delta) and C.37 (Lambda). The Spike protein (S) is a potential fragment for use as an antigen in vaccine development. This protein plays a crucial role in the first step of the infection process, as it binds to Angiotensin-Converting Enzyme 2 (ACE2) receptor and enters the host cell after binding. Immunization-induced specific antibodies against the receptor binding domain (RBD) may block and effectively prevent virus invasion. The focus of this review is the impact of spike mutated variants of SARS-CoV2 (Alpha, Beta, Gamma, Delta, and Lambda) on the efficacy of subunit recombinant vaccines. To date, a low or no significant impact on vaccine efficacy against Alpha and Delta variants has been reported. Such an impact on vaccine efficacy for Beta, Delta, Gamma, and Lambda variants may be even greater compared to the Alpha variant. Nonetheless, more comprehensive analyses are needed to assess the real impact on vaccine efficacy brought about by SARS-CoV-2 variants. |*COVID-19[MESH] |*Spike Glycoprotein, Coronavirus/genetics[MESH] |Antibodies, Viral[MESH] |Humans[MESH] |RNA, Viral[MESH] |SARS-CoV-2[MESH] |Vaccines, Subunit[MESH]The impact of spike mutated variants of SARS-CoV2 Alpha, Beta, Gamma,(epmc).pdf DeepDyve Pubget Overpricing