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10.1016/j.csbj.2021.08.029 http://scihub22266oqcxt.onion/10.1016/j.csbj.2021.08.029 34426762!8373586!34426762     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Struct+Biotechnol+J 2021 ; 19 (ä): 4684-4701 Nephropedia Template TP {{tp|p=34426762|t=2021. Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery |pdf=|usr=}}{{34426762}} gab.com Text Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery JO: Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=34426762 #FOAvip Safer and more-effective drugs are urgently needed to counter infections with the highly pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identification of efficient inhibitors to treat and prevent SARS-CoV-2 infection is a predominant focus. Encouragingly, using X-ray crystal structures of therapeutically relevant drug targets (PL(pro), M(pro), RdRp, and S glycoprotein) offers a valuable direction for anti-SARS-CoV-2 drug discovery and lead optimization through direct visualization of interactions. Computational analyses based primarily on MMPBSA calculations have also been proposed for assessing the binding stability of biomolecular structures involving the ligand and receptor. In this study, we focused on state-of-the-art X-ray co-crystal structures of the abovementioned targets complexed with newly identified small-molecule inhibitors (natural products, FDA-approved drugs, candidate drugs, and their analogues) with the assistance of computational analyses to support the precision design and screening of anti-SARS-CoV-2 drugs. Twit Text FOAVip Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery ????Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=34426762 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34426762 #FOAvip English Wikipedia <ref>{{Cite pmid|34426762}}</ref> Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery #MMPMID34426762 Wang Z; Yang L; Zhao XE Comput Struct Biotechnol J 2021[]; 19 (ä): 4684-4701 PMID34426762show ga Safer and more-effective drugs are urgently needed to counter infections with the highly pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identification of efficient inhibitors to treat and prevent SARS-CoV-2 infection is a predominant focus. Encouragingly, using X-ray crystal structures of therapeutically relevant drug targets (PL(pro), M(pro), RdRp, and S glycoprotein) offers a valuable direction for anti-SARS-CoV-2 drug discovery and lead optimization through direct visualization of interactions. Computational analyses based primarily on MMPBSA calculations have also been proposed for assessing the binding stability of biomolecular structures involving the ligand and receptor. In this study, we focused on state-of-the-art X-ray co-crystal structures of the abovementioned targets complexed with newly identified small-molecule inhibitors (natural products, FDA-approved drugs, candidate drugs, and their analogues) with the assistance of computational analyses to support the precision design and screening of anti-SARS-CoV-2 drugs. äCo-crystallization and structure determination: An effective direction(epmc).pdf DeepDyve Pubget Overpricing