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10.1055/a-1546-4291

http://scihub22266oqcxt.onion/10.1055/a-1546-4291
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34425627!ä!34425627

suck abstract from ncbi


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pmid34425627      Dtsch+Med+Wochenschr 2021 ; 146 (17): e65-e73
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  • Persistierende Beschwerden 6 Monate nach COVID-19 - Erfahrungen aus der COVID-19-Nachsorgeambulanz des Universitatsklinikums Freiburg #MMPMID34425627
  • August D; Stete K; Hilger H; Gotz V; Biever P; Hosp J; Wagner D; Kohler TC; Gerstacker K; Seufert J; Laubner K; Kern W; Rieg S
  • Dtsch Med Wochenschr 2021[Sep]; 146 (17): e65-e73 PMID34425627show ga
  • BACKGROUND: Increasing evidence suggests that some patients suffer from persistent symptoms for months after recovery from acute COVID-19. However, the clinical phenotype and its pathogenesis remain unclear. We here present data on complaints and results of a diagnostic workup of patients presenting to the post-COVID clinic at the University Medical Center Freiburg. METHODS: Retrospective data analysis of persistently symptomatic patients presenting to our clinic at least 6 months after onset of acute COVID-19. All patients were assessed by a doctor and routine laboratory analysis was carried out. Quality of life was assessed using SF-36 questionnaire. In case of specific persisting symptoms, further organ-specific diagnostic evaluation was performed, and patients were referred to respective departments/specialists. FINDINGS: 132 Patients (58 male, 74 female; mean age 53.8 years) presented to our clinic at least 6 months after COVID-19. 79 (60 %) had been treated as outpatients and 53 (40 %) as inpatients. Most common complaints were persistent fatigue (82 %) and dyspnea on exertion (61 %). Further common complaints were impairments of concentration (54 %), insomnia (43 %), and impairments of smell or taste (35 %). Quality of life was reduced in all sections of the SF-36 questionnaire, yielding a reduced working capacity. Significant pathological findings in laboratory, echocardiographic and radiological work-up were rare. Impairments in lung function tests were more common in previously hospitalized patients. CONCLUSION: Patients presenting 6 months after onset of acute COVID-19 suffer from a diverse spectrum of symptoms with impaired quality of life, also referred to as Long COVID or Post-Acute Sequelae of SARS-CoV-2 infection (PASC). Further research is needed to determine the frequency of these post-COVID syndromes and their pathogenesis, natural course and treatment options. Evaluation and management should be multi-disciplinary.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anosmia[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |COVID-19/*complications/epidemiology[MESH]
  • |Dyspnea[MESH]
  • |Fatigue[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Germany/epidemiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Post-Acute COVID-19 Syndrome[MESH]
  • |Quality of Life[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Sleep Initiation and Maintenance Disorders[MESH]
  • |Surveys and Questionnaires[MESH]
  • |Taste Disorders[MESH]


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