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10.1016/j.bbrc.2021.08.036 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2021.08.036 34425281!8364676!34425281     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2021 ; 574 (ä): 14-19 Nephropedia Template TP {{tp|p=34425281|t=2021. Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B 1 617 2 and implications for immune evasion |pdf=|usr=}}{{34425281}} gab.com Text Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B 1 617 2 and implications for immune evasion JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=34425281 #FOAvip Following the initial surges of the Alpha (B.1.1.7) and the Beta (B.1.351) variants, a more infectious Delta variant (B.1.617.2) is now surging, further deepening the health crises caused by the pandemic. The sharp rise in cases attributed to the Delta variant has made it especially disturbing and is a variant of concern. Fortunately, current vaccines offer protection against known variants of concern, including the Delta variant. However, the Delta variant has exhibited some ability to dodge the immune system as it is found that neutralizing antibodies from prior infections or vaccines are less receptive to binding with the Delta spike protein. Here, we investigated the structural changes caused by the mutations in the Delta variant's receptor-binding interface and explored the effects on binding with the ACE2 receptor as well as with neutralizing antibodies. We find that the receptor-binding beta-loop-beta motif adopts an altered but stable conformation causing separation in some of the antibody binding epitopes. Our study shows reduced binding of neutralizing antibodies and provides a possible mechanism for the immune evasion exhibited by the Delta variant. Twit Text FOAVip Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B 1 617 2 and implications for immune evasion ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=34425281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34425281 #FOAvip English Wikipedia <ref>{{Cite pmid|34425281}}</ref> Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B 1 617 2 and implications for immune evasion #MMPMID34425281 Baral P; Bhattarai N; Hossen ML; Stebliankin V; Gerstman BS; Narasimhan G; Chapagain PP Biochem Biophys Res Commun 2021[Oct]; 574 (ä): 14-19 PMID34425281show ga Following the initial surges of the Alpha (B.1.1.7) and the Beta (B.1.351) variants, a more infectious Delta variant (B.1.617.2) is now surging, further deepening the health crises caused by the pandemic. The sharp rise in cases attributed to the Delta variant has made it especially disturbing and is a variant of concern. Fortunately, current vaccines offer protection against known variants of concern, including the Delta variant. However, the Delta variant has exhibited some ability to dodge the immune system as it is found that neutralizing antibodies from prior infections or vaccines are less receptive to binding with the Delta spike protein. Here, we investigated the structural changes caused by the mutations in the Delta variant's receptor-binding interface and explored the effects on binding with the ACE2 receptor as well as with neutralizing antibodies. We find that the receptor-binding beta-loop-beta motif adopts an altered but stable conformation causing separation in some of the antibody binding epitopes. Our study shows reduced binding of neutralizing antibodies and provides a possible mechanism for the immune evasion exhibited by the Delta variant. |Amino Acids/genetics/immunology/metabolism[MESH] |Angiotensin-Converting Enzyme 2/genetics/*immunology/metabolism[MESH] |Antibodies, Viral/immunology[MESH] |Binding Sites/genetics/immunology[MESH] |COVID-19/*immunology/metabolism/virology[MESH] |Humans[MESH] |Immune Evasion/genetics/*immunology[MESH] |Molecular Dynamics Simulation[MESH] |Mutation/genetics/*immunology[MESH] |Neutralization Tests[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |SARS-CoV-2/genetics/*immunology/metabolism[MESH]Mutation-induced changes in the receptor-binding interface of the SARS(epmc).pdf DeepDyve Pubget Overpricing