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10.1371/journal.ppat.1009849 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009849 34424945!8412271!34424945     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (8): e1009849 Nephropedia Template TP {{tp|p=34424945|t=2021. Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks |pdf=|usr=}}{{34424945}} gab.com Text Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34424945 #FOAvip The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants eliciting immune escape or the ability to displace circulating lineages could emerge within individual hosts. Though growing evidence suggests that novel variants arise during prolonged infections, most infections are acute. Understanding how efficiently variants emerge and transmit among acutely-infected hosts is therefore critical for predicting the pace of long-term SARS-CoV-2 evolution. To characterize how within-host diversity is generated and propagated, we combine extensive laboratory and bioinformatic controls with metrics of within- and between-host diversity to 133 SARS-CoV-2 genomes from acutely-infected individuals. We find that within-host diversity is low and transmission bottlenecks are narrow, with very few viruses founding most infections. Within-host variants are rarely transmitted, even among individuals within the same household, and are rarely detected along phylogenetically linked infections in the broader community. These findings suggest that most variation generated within-host is lost during transmission. Twit Text FOAVip Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34424945 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34424945 #FOAvip English Wikipedia <ref>{{Cite pmid|34424945}}</ref> Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks #MMPMID34424945 Braun KM; Moreno GK; Wagner C; Accola MA; Rehrauer WM; Baker DA; Koelle K; O'Connor DH; Bedford T; Friedrich TC; Moncla LH PLoS Pathog 2021[Aug]; 17 (8): e1009849 PMID34424945show ga The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants eliciting immune escape or the ability to displace circulating lineages could emerge within individual hosts. Though growing evidence suggests that novel variants arise during prolonged infections, most infections are acute. Understanding how efficiently variants emerge and transmit among acutely-infected hosts is therefore critical for predicting the pace of long-term SARS-CoV-2 evolution. To characterize how within-host diversity is generated and propagated, we combine extensive laboratory and bioinformatic controls with metrics of within- and between-host diversity to 133 SARS-CoV-2 genomes from acutely-infected individuals. We find that within-host diversity is low and transmission bottlenecks are narrow, with very few viruses founding most infections. Within-host variants are rarely transmitted, even among individuals within the same household, and are rarely detected along phylogenetically linked infections in the broader community. These findings suggest that most variation generated within-host is lost during transmission. |*Genetic Variation[MESH] |Acute Disease[MESH] |COVID-19/transmission/*virology[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Humans[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH]Acute SARS-CoV-2 infections harbor limited within-host diversity and t(epmc).pdf DeepDyve Pubget Overpricing