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10.1080/07391102.2021.1965029 http://scihub22266oqcxt.onion/10.1080/07391102.2021.1965029 34424815!ä!34424815 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2022 ; 40 (22): 11611-11624 Nephropedia Template TP {{tp|p=34424815|t=2022. In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets M(pro) and TMPRSS2 |pdf=|usr=}}{{34424815}} gab.com Text In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets M(pro) and TMPRSS2 JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=34424815 #FOAvip COVID-19 pandemic was started in Wuhan city of China in December 2019; immensely affected global population. Herein, an effort was made to identify potential inhibitors from active phytochemicals of Pueraria tuberosa (PTY-2) via molecular docking study. Our study showed five potential inhibitors (Robinin, Genistin, Daidzin, Hydroxytuberosone, Tuberostan) against M(pro) and five inhibitors (Robinin, Anhydrotuberosin, Daidzin, Hydroxytuberosone, Stigmasterol) against TMPRSS2. Out of these, Robinin, Daidzin and Hydroxytuberosone were common inhibitors for M(pro) and TMPRSS2. Among these, Robinin showed the highest binding affinity, therefore, tested for MD simulation runs and found stable. ADMET analysis revealed the best-docked compounds are safe and follow the Lipinski Rule of Five. Thus, it could be suggested that phytochemicals of PTY-2 could serve as potential inhibitors for COVID-19 targets.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets M(pro) and TMPRSS2 ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=34424815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34424815 #FOAvip English Wikipedia <ref>{{Cite pmid|34424815}}</ref> In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets M(pro) and TMPRSS2 #MMPMID34424815 Shree P; Mishra P; Kumar P; Pandey H; Giri R; Chaube R; Garg N; Tripathi YB J Biomol Struct Dyn 2022[]; 40 (22): 11611-11624 PMID34424815show ga COVID-19 pandemic was started in Wuhan city of China in December 2019; immensely affected global population. Herein, an effort was made to identify potential inhibitors from active phytochemicals of Pueraria tuberosa (PTY-2) via molecular docking study. Our study showed five potential inhibitors (Robinin, Genistin, Daidzin, Hydroxytuberosone, Tuberostan) against M(pro) and five inhibitors (Robinin, Anhydrotuberosin, Daidzin, Hydroxytuberosone, Stigmasterol) against TMPRSS2. Out of these, Robinin, Daidzin and Hydroxytuberosone were common inhibitors for M(pro) and TMPRSS2. Among these, Robinin showed the highest binding affinity, therefore, tested for MD simulation runs and found stable. ADMET analysis revealed the best-docked compounds are safe and follow the Lipinski Rule of Five. Thus, it could be suggested that phytochemicals of PTY-2 could serve as potential inhibitors for COVID-19 targets.Communicated by Ramaswamy H. Sarma. |*COVID-19[MESH] |*Pueraria[MESH] |Computer Simulation[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Pandemics[MESH] |Protease Inhibitors[MESH]In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-1(epmc).pdf DeepDyve Pubget Overpricing