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10.7554/eLife.69661 http://scihub22266oqcxt.onion/10.7554/eLife.69661 34424199!8382293!34424199     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=34424199|t=2021. Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia |pdf=|usr=}}{{34424199}} gab.com Text Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=34424199 #FOAvip The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients with CAP renders it difficult to distinguish immune features unique to COVID-19 from the common characteristics of a dysregulated host response to pneumonia. We performed integrated single-cell transcriptomic and proteomic analyses in peripheral blood mononuclear cells from a matched cohort of eight patients with COVID-19, eight patients with CAP caused by Influenza A or other pathogens, and four non-infectious control subjects. Using this balanced, multi-omics approach, we describe shared and diverging transcriptional and phenotypic patterns-including increased levels of type I interferon-stimulated natural killer cells in COVID-19, cytotoxic CD8 T EMRA cells in both COVID-19 and influenza, and distinctive monocyte compositions between all groups-and thereby expand our understanding of the peripheral immune response in different etiologies of pneumonia. Twit Text FOAVip Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=34424199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34424199 #FOAvip English Wikipedia <ref>{{Cite pmid|34424199}}</ref> Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia #MMPMID34424199 Schuurman AR; Reijnders TDY; Saris A; Ramirez Moral I; Schinkel M; de Brabander J; van Linge C; Vermeulen L; Scicluna BP; Wiersinga WJ; Vieira Braga FA; van der Poll T Elife 2021[Aug]; 10 (ä): ä PMID34424199show ga The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients with CAP renders it difficult to distinguish immune features unique to COVID-19 from the common characteristics of a dysregulated host response to pneumonia. We performed integrated single-cell transcriptomic and proteomic analyses in peripheral blood mononuclear cells from a matched cohort of eight patients with COVID-19, eight patients with CAP caused by Influenza A or other pathogens, and four non-infectious control subjects. Using this balanced, multi-omics approach, we describe shared and diverging transcriptional and phenotypic patterns-including increased levels of type I interferon-stimulated natural killer cells in COVID-19, cytotoxic CD8 T EMRA cells in both COVID-19 and influenza, and distinctive monocyte compositions between all groups-and thereby expand our understanding of the peripheral immune response in different etiologies of pneumonia. |*Single-Cell Analysis[MESH] |Adult[MESH] |COVID-19/*immunology[MESH] |Community-Acquired Infections/*immunology[MESH] |Female[MESH] |Humans[MESH] |Influenza, Human/*immunology[MESH] |Leukocytes, Mononuclear/cytology/immunology[MESH] |Male[MESH]Integrated single-cell analysis unveils diverging immune features of C(epmc).pdf DeepDyve Pubget Overpricing