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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Elife 2021 ; 10 (ä): ä Nephropedia Template TP
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Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia #MMPMID34424199
Schuurman AR; Reijnders TDY; Saris A; Ramirez Moral I; Schinkel M; de Brabander J; van Linge C; Vermeulen L; Scicluna BP; Wiersinga WJ; Vieira Braga FA; van der Poll T
Elife 2021[Aug]; 10 (ä): ä PMID34424199show ga
The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients with CAP renders it difficult to distinguish immune features unique to COVID-19 from the common characteristics of a dysregulated host response to pneumonia. We performed integrated single-cell transcriptomic and proteomic analyses in peripheral blood mononuclear cells from a matched cohort of eight patients with COVID-19, eight patients with CAP caused by Influenza A or other pathogens, and four non-infectious control subjects. Using this balanced, multi-omics approach, we describe shared and diverging transcriptional and phenotypic patterns-including increased levels of type I interferon-stimulated natural killer cells in COVID-19, cytotoxic CD8 T EMRA cells in both COVID-19 and influenza, and distinctive monocyte compositions between all groups-and thereby expand our understanding of the peripheral immune response in different etiologies of pneumonia.