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10.1080/09537104.2021.1967918

http://scihub22266oqcxt.onion/10.1080/09537104.2021.1967918
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34423724!ä!34423724

suck abstract from ncbi


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pmid34423724      Platelets 2022 ; 33 (3): 471-478
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  • Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects #MMPMID34423724
  • Salva O; Alasino R; Giller C; Borello J; Doresky A; Karayan G; Beltramo D
  • Platelets 2022[Apr]; 33 (3): 471-478 PMID34423724show ga
  • We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate (AHI). Results show that after 24 h of nebulization with AHI, circulating platelets shows an increase about 40% at 24 h and reach 65% at 96 h. In patients with platelets content below 200,000 by microliter the increase was 49% and 79% at 24 and 96 h respectively. In patients with platelets above 200,000 by microliter the increase was 24% and 31% at 24 and 96 h, respectively. The increase of platelets via AHI was similar in both, men and women.To evaluate whether this action of AHI was related to platelets from COVID-19 positive patients or also for healthy people, two controls were included: one of them with 10 healthy volunteers and another one with COVID-19 positive patients hospitalized and treated only with Dexa-Enoxa. Results show that, in healthy volunteers, the number of circulating platelets remains unchanged even after 7 days of treatment with AHI. In COVID-19 positive patients treated only with Dexa-Enoxa for 4 days, platelets increased only 16%.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/blood[MESH]
  • |Adult[MESH]
  • |Blood Platelets/*metabolism[MESH]
  • |Enoxaparin/*administration & dosage[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Ibuprofen/*administration & dosage[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nebulizers and Vaporizers[MESH]
  • |Platelet Count[MESH]


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