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10.1155/2021/9987931

http://scihub22266oqcxt.onion/10.1155/2021/9987931
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34423043!8376466!34423043
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suck abstract from ncbi


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pmid34423043      Biomed+Res+Int 2021 ; 2021 (ä): 9987931
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  • Prognostic Value of Immune-Inflammatory Index in PSI IV-V Patients with COVID-19 #MMPMID34423043
  • Han R; Su H; Guo G; Wang Q; Ma J; Li Z; Huang S; Ni Y; Hu R; Huang D; Zhou H
  • Biomed Res Int 2021[]; 2021 (ä): 9987931 PMID34423043show ga
  • OBJECTIVE: Respiratory failure is the leading cause of mortality in COVID-19 patients, characterized by a generalized disbalance of inflammation. The aim of this study was to investigate the relationship between immune-inflammatory index and mortality in PSI IV-V patients with COVID-19. METHODS: We retrospectively reviewed the medical records of COVID-19 patients from Feb. to Apr. 2020 in the Zhongfa Xincheng Branch of Tongji Hospital, Wuhan, China. Patients who presented high severity of COVID-19-related pneumonia were enrolled for further analysis according to the Pneumonia Severity Index (PSI) tool. RESULTS: A total of 101 patients diagnosed with COVID-19 were identified at initial research. The survival analysis revealed that mortality of the PSI IV-V cohort was significantly higher than the PSI I-III group (p = 0.0003). The overall mortality in PSI IV-V patients was 32.1% (9/28). The fatal cases of the PSI IV-V group had a higher level of procalcitonin (p = 0.022) and neutrophil-to-lymphocyte ratio (p = 0.033) compared with the survivors. Procalcitonin was the most sensitive predictor of mortality for the severe COVID-19 population with area under receiver operating characteristic curve of 0.78, higher than the neutrophil-to-lymphocyte ratio (0.75) and total lymphocyte (0.68) and neutrophil (0.67) counts. CONCLUSION: Procalcitonin and neutrophil-to-lymphocyte ratio may potentially be effective predictors for mortality in PSI IV-V patients with COVID-19. Increased procalcitonin and neutrophil-to-lymphocyte ratio were associated with greater risk of mortality.
  • |*Pandemics[MESH]
  • |*SARS-CoV-2[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/*immunology/mortality/*physiopathology[MESH]
  • |China/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammation/immunology/physiopathology[MESH]
  • |Lymphocytes/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neutrophils/immunology[MESH]
  • |Pneumonia, Viral/immunology/mortality/physiopathology[MESH]
  • |Procalcitonin/blood[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |Severity of Illness Index[MESH]


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