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10.3389/fimmu.2021.692729 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.692729 34421902!8374943!34421902     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 692729 Nephropedia Template TP {{tp|p=34421902|t=2021. BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity |pdf=|usr=}}{{34421902}} gab.com Text BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34421902 #FOAvip Epidemiological studies and clinical trials suggest Bacillus Calmette-Guerin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent or reduce the severity of COVID-19. However, the mechanism by which BCG vaccination can induce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses is unknown. Here, we identify 8 novel BCG-derived peptides with significant sequence homology to either SARS-CoV-2 NSP3 or NSP13-derived peptides. Using an in vitro co-culture system, we show that human CD4+ and CD8+ T cells primed with a BCG-derived peptide developed enhanced reactivity to its corresponding homologous SARS-CoV-2-derived peptide. As expected, HLA differences between individuals meant that not all persons developed immunogenic responses to all 8 BCG-derived peptides. Nevertheless, all of the 20 individuals that were primed with BCG-derived peptides developed enhanced T cell reactivity to at least 7 of 8 SARS-CoV-2-derived peptides. These findings provide an in vitro mechanism that may account, in part, for the epidemiologic observation that BCG vaccination confers some protection from COVID-19. Twit Text FOAVip BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34421902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34421902 #FOAvip English Wikipedia <ref>{{Cite pmid|34421902}}</ref> BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity #MMPMID34421902 Eggenhuizen PJ; Ng BH; Chang J; Fell AL; Cheong RMY; Wong WY; Gan PY; Holdsworth SR; Ooi JD Front Immunol 2021[]; 12 (ä): 692729 PMID34421902show ga Epidemiological studies and clinical trials suggest Bacillus Calmette-Guerin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent or reduce the severity of COVID-19. However, the mechanism by which BCG vaccination can induce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses is unknown. Here, we identify 8 novel BCG-derived peptides with significant sequence homology to either SARS-CoV-2 NSP3 or NSP13-derived peptides. Using an in vitro co-culture system, we show that human CD4+ and CD8+ T cells primed with a BCG-derived peptide developed enhanced reactivity to its corresponding homologous SARS-CoV-2-derived peptide. As expected, HLA differences between individuals meant that not all persons developed immunogenic responses to all 8 BCG-derived peptides. Nevertheless, all of the 20 individuals that were primed with BCG-derived peptides developed enhanced T cell reactivity to at least 7 of 8 SARS-CoV-2-derived peptides. These findings provide an in vitro mechanism that may account, in part, for the epidemiologic observation that BCG vaccination confers some protection from COVID-19. |*Cross Reactions[MESH] |Adult[MESH] |BCG Vaccine/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/immunology/prevention & control[MESH] |Cells, Cultured[MESH] |Coculture Techniques[MESH] |Female[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Male[MESH] |SARS-CoV-2/*immunology[MESH] |Sequence Analysis, Protein[MESH] |Sequence Homology[MESH] |Vaccines, Subunit/immunology[MESH]BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity(epmc).pdf DeepDyve Pubget Overpricing