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10.1073/pnas.2103154118 http://scihub22266oqcxt.onion/10.1073/pnas.2103154118 34417349!8433494!34417349     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (36): ä Nephropedia Template TP {{tp|p=34417349|t=2021. SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma |pdf=|usr=}}{{34417349}} gab.com Text SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34417349 #FOAvip To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for seven passages, but, after 45 d, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed, at day 80, by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization. Computational modeling predicts that the deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies. The recent emergence in the United Kingdom, South Africa, Brazil, and Japan of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed. Twit Text FOAVip SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34417349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34417349 #FOAvip English Wikipedia <ref>{{Cite pmid|34417349}}</ref> SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma #MMPMID34417349 Andreano E; Piccini G; Licastro D; Casalino L; Johnson NV; Paciello I; Dal Monego S; Pantano E; Manganaro N; Manenti A; Manna R; Casa E; Hyseni I; Benincasa L; Montomoli E; Amaro RE; McLellan JS; Rappuoli R Proc Natl Acad Sci U S A 2021[Sep]; 118 (36): ä PMID34417349show ga To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for seven passages, but, after 45 d, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed, at day 80, by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization. Computational modeling predicts that the deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies. The recent emergence in the United Kingdom, South Africa, Brazil, and Japan of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed. |*Amino Acid Substitution[MESH] |Angiotensin-Converting Enzyme 2/chemistry/genetics/*immunology[MESH] |Animals[MESH] |Antibodies, Neutralizing/chemistry/genetics/*immunology/pharmacology[MESH] |Antibodies, Viral/chemistry/genetics/*immunology/pharmacology[MESH] |Binding Sites[MESH] |COVID-19/genetics/*immunology/virology[MESH] |Chlorocebus aethiops[MESH] |Convalescence[MESH] |Gene Expression[MESH] |Humans[MESH] |Immune Evasion[MESH] |Immune Sera/chemistry[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Neutralization Tests[MESH] |Protein Binding[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |Protein Interaction Domains and Motifs[MESH] |SARS-CoV-2/drug effects/*genetics/immunology/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/*immunology[MESH]SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent pla(epmc).pdf DeepDyve Pubget Overpricing