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10.1016/j.celrep.2021.109627 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109627 34416153!8352667!34416153     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 36 (9): 109627 Nephropedia Template TP {{tp|p=34416153|t=2021. One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening |pdf=|usr=}}{{34416153}} gab.com Text One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34416153 #FOAvip The potential emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) escape mutants is a threat to the efficacy of existing vaccines and neutralizing antibody (nAb) therapies. An understanding of the antibody/S escape mutation landscape is urgently needed to preemptively address this threat. Here we describe a rapid method to identify escape mutants for nAbs targeting the S receptor binding site. We identified escape mutants for five nAbs, including three from the public germline class VH3-53 elicited by natural coronavirus disease 2019 (COVID-19) infection. Escape mutations predominantly mapped to the periphery of the angiotensin-converting enzyme 2 (ACE2) recognition site on the RBD with K417, D420, Y421, F486, and Q493 as notable hotspots. We provide libraries, methods, and software as an openly available community resource to accelerate new therapeutic strategies against SARS-CoV-2. Twit Text FOAVip One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34416153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34416153 #FOAvip English Wikipedia <ref>{{Cite pmid|34416153}}</ref> One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening #MMPMID34416153 Francino-Urdaniz IM; Steiner PJ; Kirby MB; Zhao F; Haas CM; Barman S; Rhodes ER; Leonard AC; Peng L; Sprenger KG; Jardine JG; Whitehead TA Cell Rep 2021[Aug]; 36 (9): 109627 PMID34416153show ga The potential emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) escape mutants is a threat to the efficacy of existing vaccines and neutralizing antibody (nAb) therapies. An understanding of the antibody/S escape mutation landscape is urgently needed to preemptively address this threat. Here we describe a rapid method to identify escape mutants for nAbs targeting the S receptor binding site. We identified escape mutants for five nAbs, including three from the public germline class VH3-53 elicited by natural coronavirus disease 2019 (COVID-19) infection. Escape mutations predominantly mapped to the periphery of the angiotensin-converting enzyme 2 (ACE2) recognition site on the RBD with K417, D420, Y421, F486, and Q493 as notable hotspots. We provide libraries, methods, and software as an openly available community resource to accelerate new therapeutic strategies against SARS-CoV-2. äOne-shot identification of SARS-CoV-2 S RBD escape mutants using yeast(epmc).pdf DeepDyve Pubget Overpricing