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10.1038/s41423-021-00750-4 http://scihub22266oqcxt.onion/10.1038/s41423-021-00750-4 34413488!8374113!34413488     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2021 ; 18 (10): 2325-2333 Nephropedia Template TP {{tp|p=34413488|t=2021. Activation or exhaustion of CD8(+) T cells in patients with COVID-19 |pdf=|usr=}}{{34413488}} gab.com Text Activation or exhaustion of CD8(+) T cells in patients with COVID-19 JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34413488 #FOAvip In addition to CD4(+) T cells and neutralizing antibodies, CD8(+) T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8(+) T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8(+) T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8(+) T cells from patients with COVID-19. However, whether CD8(+) T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8(+) T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8(+) T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8(+) T cells and discuss long-term SARS-CoV-2-specific CD8(+) T-cell memory. Twit Text FOAVip Activation or exhaustion of CD8(+) T cells in patients with COVID-19 ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34413488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34413488 #FOAvip English Wikipedia <ref>{{Cite pmid|34413488}}</ref> Activation or exhaustion of CD8(+) T cells in patients with COVID-19 #MMPMID34413488 Rha MS; Shin EC Cell Mol Immunol 2021[Oct]; 18 (10): 2325-2333 PMID34413488show ga In addition to CD4(+) T cells and neutralizing antibodies, CD8(+) T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8(+) T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8(+) T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8(+) T cells from patients with COVID-19. However, whether CD8(+) T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8(+) T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8(+) T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8(+) T cells and discuss long-term SARS-CoV-2-specific CD8(+) T-cell memory. |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*immunology[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Lymphocyte Activation[MESH]Activation or exhaustion of CD8(+) T cells in patients with COVID-19 (epmc).pdf DeepDyve Pubget Overpricing