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10.1038/s41587-021-01037-9 http://scihub22266oqcxt.onion/10.1038/s41587-021-01037-9 34408314!ä!34408314 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2022 ; 40 (3): 319-324 Nephropedia Template TP {{tp|p=34408314|t=2022. Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children |pdf=|usr=}}{{34408314}} gab.com Text Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34408314 #FOAvip Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying protection in younger age groups remain unknown. Here we characterize the single-cell transcriptional landscape in the upper airways of SARS-CoV-2-negative (n = 18) and age-matched SARS-CoV-2-positive (n = 24) children and corresponding samples from adults (n = 44), covering an age range of 4 weeks to 77 years. Children displayed higher basal expression of relevant pattern recognition receptors such as MDA5 (IFIH1) and RIG-I (DDX58) in upper airway epithelial cells, macrophages and dendritic cells, resulting in stronger innate antiviral responses upon SARS-CoV-2 infection than in adults. We further detected distinct immune cell subpopulations including KLRC1 (NKG2A)(+) cytotoxic T cells and a CD8(+) T cell population with a memory phenotype occurring predominantly in children. Our study provides evidence that the airway immune cells of children are primed for virus sensing, resulting in a stronger early innate antiviral response to SARS-CoV-2 infection than in adults. Twit Text FOAVip Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34408314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34408314 #FOAvip English Wikipedia <ref>{{Cite pmid|34408314}}</ref> Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children #MMPMID34408314 Loske J; Rohmel J; Lukassen S; Stricker S; Magalhaes VG; Liebig J; Chua RL; Thurmann L; Messingschlager M; Seegebarth A; Timmermann B; Klages S; Ralser M; Sawitzki B; Sander LE; Corman VM; Conrad C; Laudi S; Binder M; Trump S; Eils R; Mall MA; Lehmann I Nat Biotechnol 2022[Mar]; 40 (3): 319-324 PMID34408314show ga Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying protection in younger age groups remain unknown. Here we characterize the single-cell transcriptional landscape in the upper airways of SARS-CoV-2-negative (n = 18) and age-matched SARS-CoV-2-positive (n = 24) children and corresponding samples from adults (n = 44), covering an age range of 4 weeks to 77 years. Children displayed higher basal expression of relevant pattern recognition receptors such as MDA5 (IFIH1) and RIG-I (DDX58) in upper airway epithelial cells, macrophages and dendritic cells, resulting in stronger innate antiviral responses upon SARS-CoV-2 infection than in adults. We further detected distinct immune cell subpopulations including KLRC1 (NKG2A)(+) cytotoxic T cells and a CD8(+) T cell population with a memory phenotype occurring predominantly in children. Our study provides evidence that the airway immune cells of children are primed for virus sensing, resulting in a stronger early innate antiviral response to SARS-CoV-2 infection than in adults. |*Immunity, Innate[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Bronchi/*immunology/*virology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19/*immunology/*virology[MESH] |Child[MESH] |Child, Preschool[MESH] |DEAD Box Protein 58/metabolism[MESH] |Dendritic Cells/immunology[MESH] |Epithelial Cells/immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Interferon-Induced Helicase, IFIH1/metabolism[MESH] |Macrophages/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Receptors, Immunologic/metabolism[MESH] |SARS-CoV-2/*immunology[MESH] |Single-Cell Analysis[MESH] |T-Lymphocytes, Cytotoxic/immunology[MESH]Pre-activated antiviral innate immunity in the upper airways controls (epmc).pdf DeepDyve Pubget Overpricing