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10.1126/sciadv.abf8609 http://scihub22266oqcxt.onion/10.1126/sciadv.abf8609 34407940!8373124!34407940     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34407940&cmd=llinks): Failed to open stream: HTTP request failed! 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Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity |pdf=|usr=}}{{34407940}} gab.com Text Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34407940 #FOAvip Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric patients typically experiencing less severe infection than adults and especially the elderly. The basis for this difference is unclear. We find that mRNA and protein expression of angiotensin-converting enzyme 2 (ACE2), the cell entry receptor for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19, increases with advancing age in distal lung epithelial cells. However, in humans, ACE2 expression exhibits high levels of intra- and interindividual heterogeneity. Further, cells infected with SARS-CoV-2 experience endoplasmic reticulum stress, triggering an unfolded protein response and caspase-mediated apoptosis, a natural host defense system that halts virion production. Apoptosis of infected cells can be selectively induced by treatment with apoptosis-modulating BH3 mimetic drugs. Notably, epithelial cells within young lungs and airways are more primed to undergo apoptosis than those in adults, which may naturally hinder virion production and support milder COVID-19 severity. Twit Text FOAVip Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34407940 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34407940 #FOAvip English Wikipedia <ref>{{Cite pmid|34407940}}</ref> Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity #MMPMID34407940 Inde Z; Croker BA; Yapp C; Joshi GN; Spetz J; Fraser C; Qin X; Xu L; Deskin B; Ghelfi E; Webb G; Carlin AF; Zhu YP; Leibel SL; Garretson AF; Clark AE; Duran JM; Pretorius V; Crotty-Alexander LE; Li C; Lee JC; Sodhi C; Hackam DJ; Sun X; Hata AN; Kobzik L; Miller J; Park JA; Brownfield D; Jia H; Sarosiek KA Sci Adv 2021[Aug]; 7 (34): ä PMID34407940show ga Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric patients typically experiencing less severe infection than adults and especially the elderly. The basis for this difference is unclear. We find that mRNA and protein expression of angiotensin-converting enzyme 2 (ACE2), the cell entry receptor for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19, increases with advancing age in distal lung epithelial cells. However, in humans, ACE2 expression exhibits high levels of intra- and interindividual heterogeneity. Further, cells infected with SARS-CoV-2 experience endoplasmic reticulum stress, triggering an unfolded protein response and caspase-mediated apoptosis, a natural host defense system that halts virion production. Apoptosis of infected cells can be selectively induced by treatment with apoptosis-modulating BH3 mimetic drugs. Notably, epithelial cells within young lungs and airways are more primed to undergo apoptosis than those in adults, which may naturally hinder virion production and support milder COVID-19 severity. |Age Factors[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2/*genetics/metabolism[MESH] |Animals[MESH] |Apoptosis/*genetics[MESH] |COVID-19/*genetics/metabolism/virology[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Female[MESH] |Gene Expression Profiling/*methods[MESH] |Humans[MESH] |Infant[MESH] |Lung/cytology/metabolism/virology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Middle Aged[MESH] |SARS-CoV-2/physiology[MESH] |Severity of Illness Index[MESH] |Vero Cells[MESH]Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death(epmc).pdf DeepDyve Pubget Overpricing