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10.1093/bioinformatics/btab597 http://scihub22266oqcxt.onion/10.1093/bioinformatics/btab597 34406356!10060723!34406356     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34406356&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioinformatics 2021 ; 38 (1): 1-8 Nephropedia Template TP {{tp|p=34406356|t=2021. coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies |pdf=|usr=}}{{34406356}} gab.com Text coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=34406356 #FOAvip MOTIVATION: The COVID-19 pandemic has ignited a broad scientific interest in viral research in general and coronavirus research in particular. The identification and characterization of viral species in natural reservoirs typically involves de novo assembly. However, existing genome, metagenome and transcriptome assemblers often are not able to assemble many viruses (including coronaviruses) into a single contig. Coverage variation between datasets and within dataset, presence of close strains, splice variants and contamination set a high bar for assemblers to process viral datasets with diverse properties. RESULTS: We developed coronaSPAdes, a novel assembler for RNA viral species recovery in general and coronaviruses in particular. coronaSPAdes leverages the knowledge about viral genome structures to improve assembly extending ideas initially implemented in biosyntheticSPAdes. We have shown that coronaSPAdes outperforms existing SPAdes modes and other popular short-read metagenome and viral assemblers in the recovery of full-length RNA viral genomes. AVAILABILITY AND IMPLEMENTATION: coronaSPAdes version used in this article is a part of SPAdes 3.15 release and is freely available at http://cab.spbu.ru/software/spades. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Twit Text FOAVip coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=34406356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34406356 #FOAvip English Wikipedia <ref>{{Cite pmid|34406356}}</ref> coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies #MMPMID34406356 Meleshko D; Hajirasouliha I; Korobeynikov A Bioinformatics 2021[Dec]; 38 (1): 1-8 PMID34406356show ga MOTIVATION: The COVID-19 pandemic has ignited a broad scientific interest in viral research in general and coronavirus research in particular. The identification and characterization of viral species in natural reservoirs typically involves de novo assembly. However, existing genome, metagenome and transcriptome assemblers often are not able to assemble many viruses (including coronaviruses) into a single contig. Coverage variation between datasets and within dataset, presence of close strains, splice variants and contamination set a high bar for assemblers to process viral datasets with diverse properties. RESULTS: We developed coronaSPAdes, a novel assembler for RNA viral species recovery in general and coronaviruses in particular. coronaSPAdes leverages the knowledge about viral genome structures to improve assembly extending ideas initially implemented in biosyntheticSPAdes. We have shown that coronaSPAdes outperforms existing SPAdes modes and other popular short-read metagenome and viral assemblers in the recovery of full-length RNA viral genomes. AVAILABILITY AND IMPLEMENTATION: coronaSPAdes version used in this article is a part of SPAdes 3.15 release and is freely available at http://cab.spbu.ru/software/spades. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. |*COVID-19[MESH] |*Software[MESH] |Genome, Viral[MESH] |Humans[MESH] |Metagenome[MESH]coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies (epmc).pdf DeepDyve Pubget Overpricing