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10.1080/10428194.2021.1966782

http://scihub22266oqcxt.onion/10.1080/10428194.2021.1966782
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34405767!ä!34405767

suck abstract from ncbi


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pmid34405767      Leuk+Lymphoma 2021 ; 62 (14): 3384-3393
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  • COVID-19 among patients with hematological malignancies: a national Israeli retrospective analysis with special emphasis on treatment and outcome #MMPMID34405767
  • Levy I; Lavi A; Zimran E; Grisariu S; Aumann S; Itchaki G; Berger T; Raanani P; Harel R; Aviv A; Lavi N; Zuckerman T; Shvidel L; Jarchowsky O; Ellis M; Herzog Tzarfati K; Koren-Michowitz M; Sherf Y; Levi I; Sofer O; Shpilberg O; Dally N; Suriu C; Braester A; Ben Barouch S; Leiba M; Goldstein D; Sarid N; Yeganeh S; Halloun J; Mittelman M; Tadmor T
  • Leuk Lymphoma 2021[Dec]; 62 (14): 3384-3393 PMID34405767show ga
  • This national Israeli multicenter retrospective study aimed to characterize the clinical course of COVID-19 infection among patients with hematological malignancies, with special emphasis on treatment efficacy and outcome. Clinical and laboratory data from haemato-oncological patients diagnosed with COVID-19 from 16 medical centers were centrally reported. Multivariate regression analyses were used to determine variables associated with severe disease, hospitalization, and mortality. In total, 313 patients were included: 103 (35.7%) developed severe/critical respiratory infection, 178 (61.4%) were hospitalized, and 60 (20.0%) died. Age > 70 years was associated with severe/critical disease (p = 0.036) and mortality (p = 0.023), hypertension with severe/critical disease (p = 0.046) and hospitalization (p = 0.001), active haemato-oncological treatment with hospitalization (p = 0.009), and remdesivir treatment was associated with decreased mortality (p = 0.021). Convalescent plasma, enoxaparin, and corticosteroids resulted in no clinical benefit. In conclusion, COVID-19 infection seems particularly severe in patients with hematological malignancies, and of all examined therapies, remdesivir appears to be the most effective.
  • |*COVID-19/therapy[MESH]
  • |*Hematologic Neoplasms/complications/epidemiology/therapy[MESH]
  • |Aged[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Retrospective Studies[MESH]


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