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10.1016/j.eclinm.2021.101079 http://scihub22266oqcxt.onion/10.1016/j.eclinm.2021.101079 34405138!8360709!34405138     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EClinicalMedicine 2021 ; 39 (ä): 101079 Nephropedia Template TP {{tp|p=34405138|t=2021. COVID-19 and the effects on pulmonary function following infection: A retrospective analysis |pdf=|usr=}}{{34405138}} gab.com Text COVID-19 and the effects on pulmonary function following infection: A retrospective analysis JO: EClinicalMedicine http://www.kidney.de/pget.php?&tw=1&pmid=34405138 #FOAvip BACKGROUND: The coronavirus disease 2019 (COVID-19) has been identified in over 110 million people with no studies comparing pre-infection pulmonary function to post-infection. This study's aim was to compare pre-infection and post-infection pulmonary function tests (PFT) in COVID-19 infected patients to better delineate between preexisting abnormalities and effects of the virus. METHODS: This was a retrospective multi-center cohort study. Patients were identified based on having COVID-19 and a pre- and post-infection PFT within one year of infection during the time period of March 1, 2020 to November 10, 2020. FINDINGS: There was a total of 80 patients, with an even split in gender; the majority were white (n?=?70, 87.5%) and never smokers (n?=?42, 52.5%). The majority had mild to moderate COVID-19 disease (n?=?60, 75.1%) with 25 (31.2%) requiring hospitalization. There was no difference between the pre- and post-PFT data, specifically with the forced vital capacity (FVC) (p?=?0.52), forced expiratory volume in 1 s (FEV1)(p?=?0.96), FEV1/FVC(p?=?0.66), total lung capacity (TLC) (p?=?0.21), and diffusion capacity (DLCO)(p?=?0.88). There was no difference in the PFT when analyzed by hospitalization and disease severity. After adjusting for potential confounders, interstitial lung disease (ILD) was independently associated with a decreased FEV1 (-2.6 [95% CI, -6.7 to - 1.6] vs. -10.3 [95% CI, -17.7 to -2.9]; p?=?0.03) and an increasing age (p?=?0.01) and cystic fibrosis (-1.1 [95% CI, -4.5 to- 2.4] vs. -36.5 [95% CI, -52.1 to -21.0]; p < 0.01) were associated with decreasing FVC when comparing pre and post infection PFT. Only increasing age was independently associated with a reduction in TLC (p?=?0.01) and DLCO (p?=?0.02) before and after infection. INTERPRETATION: This study showed that there is no difference in pulmonary function as measured by PFT before and after COVID-19 infection in non-critically ill classified patients. There could be a relationship with certain underlying lung diseases (interstitial lung disease and cystic fibrosis) and decreased lung function following infection. This information should aid clinicians in their interpretation of pulmonary function tests obtained following COVID-19 infection. FUNDING: No funding was obtained for this study. Twit Text FOAVip COVID-19 and the effects on pulmonary function following infection: A retrospective analysis ????EClinicalMedicine http://www.kidney.de/pget.php?&tw=1&pmid=34405138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34405138 #FOAvip English Wikipedia <ref>{{Cite pmid|34405138}}</ref> COVID-19 and the effects on pulmonary function following infection: A retrospective analysis #MMPMID34405138 Lewis KL; Helgeson SA; Tatari MM; Mallea JM; Baig HZ; Patel NM EClinicalMedicine 2021[Sep]; 39 (ä): 101079 PMID34405138show ga BACKGROUND: The coronavirus disease 2019 (COVID-19) has been identified in over 110 million people with no studies comparing pre-infection pulmonary function to post-infection. This study's aim was to compare pre-infection and post-infection pulmonary function tests (PFT) in COVID-19 infected patients to better delineate between preexisting abnormalities and effects of the virus. METHODS: This was a retrospective multi-center cohort study. Patients were identified based on having COVID-19 and a pre- and post-infection PFT within one year of infection during the time period of March 1, 2020 to November 10, 2020. FINDINGS: There was a total of 80 patients, with an even split in gender; the majority were white (n?=?70, 87.5%) and never smokers (n?=?42, 52.5%). The majority had mild to moderate COVID-19 disease (n?=?60, 75.1%) with 25 (31.2%) requiring hospitalization. There was no difference between the pre- and post-PFT data, specifically with the forced vital capacity (FVC) (p?=?0.52), forced expiratory volume in 1 s (FEV1)(p?=?0.96), FEV1/FVC(p?=?0.66), total lung capacity (TLC) (p?=?0.21), and diffusion capacity (DLCO)(p?=?0.88). There was no difference in the PFT when analyzed by hospitalization and disease severity. After adjusting for potential confounders, interstitial lung disease (ILD) was independently associated with a decreased FEV1 (-2.6 [95% CI, -6.7 to - 1.6] vs. -10.3 [95% CI, -17.7 to -2.9]; p?=?0.03) and an increasing age (p?=?0.01) and cystic fibrosis (-1.1 [95% CI, -4.5 to- 2.4] vs. -36.5 [95% CI, -52.1 to -21.0]; p < 0.01) were associated with decreasing FVC when comparing pre and post infection PFT. Only increasing age was independently associated with a reduction in TLC (p?=?0.01) and DLCO (p?=?0.02) before and after infection. INTERPRETATION: This study showed that there is no difference in pulmonary function as measured by PFT before and after COVID-19 infection in non-critically ill classified patients. There could be a relationship with certain underlying lung diseases (interstitial lung disease and cystic fibrosis) and decreased lung function following infection. This information should aid clinicians in their interpretation of pulmonary function tests obtained following COVID-19 infection. FUNDING: No funding was obtained for this study. äCOVID-19 and the effects on pulmonary function following infection: A (epmc).pdf DeepDyve Pubget Overpricing