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10.1080/21623945.2021.1965315 http://scihub22266oqcxt.onion/10.1080/21623945.2021.1965315 34402717!8381800!34402717     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adipocyte 2021 ; 10 (1): 408-411 Nephropedia Template TP {{tp|p=34402717|t=2021. Resveratrol supplementation reduces ACE2 expression in human adipose tissue |pdf=|usr=}}{{34402717}} gab.com Text Resveratrol supplementation reduces ACE2 expression in human adipose tissue JO: Adipocyte http://www.kidney.de/pget.php?&tw=1&pmid=34402717 #FOAvip Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we investigated the effects of 30-days resveratrol supplementation on RAS components in AT and skeletal muscle in men with obesity in a placebo-controlled cross-over study. Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components. These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19. Twit Text FOAVip Resveratrol supplementation reduces ACE2 expression in human adipose tissue ????Adipocyte http://www.kidney.de/pget.php?&tw=1&pmid=34402717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34402717 #FOAvip English Wikipedia <ref>{{Cite pmid|34402717}}</ref> Resveratrol supplementation reduces ACE2 expression in human adipose tissue #MMPMID34402717 de Ligt M; Hesselink MKC; Jorgensen J; Hoebers N; Blaak EE; Goossens GH Adipocyte 2021[Dec]; 10 (1): 408-411 PMID34402717show ga Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we investigated the effects of 30-days resveratrol supplementation on RAS components in AT and skeletal muscle in men with obesity in a placebo-controlled cross-over study. Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components. These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19. |Adipose Tissue/cytology/*metabolism[MESH] |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |COVID-19/pathology/virology[MESH] |Cross-Over Studies[MESH] |Dietary Supplements[MESH] |Double-Blind Method[MESH] |Down-Regulation/drug effects[MESH] |Humans[MESH] |Leptin/genetics/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Obesity/drug therapy/pathology[MESH] |Placebo Effect[MESH] |Receptor, Angiotensin, Type 1/genetics/metabolism[MESH] |Resveratrol/*administration & dosage/pharmacology[MESH]Resveratrol supplementation reduces ACE2 expression in human adipose t(epmc).pdf DeepDyve Pubget Overpricing