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10.1093/bfgp/elab037 http://scihub22266oqcxt.onion/10.1093/bfgp/elab037 34402498!8385967!34402498     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Funct+Genomics 2022 ; 21 (2): 90-102 Nephropedia Template TP {{tp|p=34402498|t=2022. Infection outcome needs two to tango: human host and the pathogen |pdf=|usr=}}{{34402498}} gab.com Text Infection outcome needs two to tango: human host and the pathogen JO: Brief Funct Genomics http://www.kidney.de/pget.php?&tw=1&pmid=34402498 #FOAvip Infectious diseases are potential drivers for human evolution, through a complex, continuous and dynamic interaction between the host and the pathogen/s. It is this dynamic interaction that contributes toward the clinical outcome of a pathogenic disease. These are modulated by contributions from the human genetic variants, transcriptional response (including noncoding RNA) and the pathogen's genome architecture. Modern genomic tools and techniques have been crucial for the detection and genomic characterization of pathogens with respect to the emerging infectious diseases. Aided by next-generation sequencing (NGS), risk stratification of host population/s allows for the identification of susceptible subgroups and better disease management. Nevertheless, many challenges to a general understanding of host-pathogen interactions remain. In this review, we elucidate how a better understanding of the human host-pathogen interplay can substantially enhance, and in turn benefit from, current and future applications of multi-omics based approaches in infectious and rare diseases. This includes the RNA-level response, which modulates the disease severity and outcome. The need to understand the role of human genetic variants in disease severity and clinical outcome has been further highlighted during the Coronavirus disease 2019 (COVID-19) pandemic. This would enhance and contribute toward our future pandemic preparedness. Twit Text FOAVip Infection outcome needs two to tango: human host and the pathogen ????Brief Funct Genomics http://www.kidney.de/pget.php?&tw=1&pmid=34402498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34402498 #FOAvip English Wikipedia <ref>{{Cite pmid|34402498}}</ref> Infection outcome needs two to tango: human host and the pathogen #MMPMID34402498 Maurya R; Kanakan A; Vasudevan JS; Chattopadhyay P; Pandey R Brief Funct Genomics 2022[Apr]; 21 (2): 90-102 PMID34402498show ga Infectious diseases are potential drivers for human evolution, through a complex, continuous and dynamic interaction between the host and the pathogen/s. It is this dynamic interaction that contributes toward the clinical outcome of a pathogenic disease. These are modulated by contributions from the human genetic variants, transcriptional response (including noncoding RNA) and the pathogen's genome architecture. Modern genomic tools and techniques have been crucial for the detection and genomic characterization of pathogens with respect to the emerging infectious diseases. Aided by next-generation sequencing (NGS), risk stratification of host population/s allows for the identification of susceptible subgroups and better disease management. Nevertheless, many challenges to a general understanding of host-pathogen interactions remain. In this review, we elucidate how a better understanding of the human host-pathogen interplay can substantially enhance, and in turn benefit from, current and future applications of multi-omics based approaches in infectious and rare diseases. This includes the RNA-level response, which modulates the disease severity and outcome. The need to understand the role of human genetic variants in disease severity and clinical outcome has been further highlighted during the Coronavirus disease 2019 (COVID-19) pandemic. This would enhance and contribute toward our future pandemic preparedness. |*COVID-19/genetics[MESH] |Genomics/methods[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH]Infection outcome needs two to tango: human host and the pathogen (epmc).pdf DeepDyve Pubget Overpricing