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10.1097/MEG.0000000000002267

http://scihub22266oqcxt.onion/10.1097/MEG.0000000000002267
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34402469!8734573!34402469
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suck abstract from ncbi


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pmid34402469      Eur+J+Gastroenterol+Hepatol 2021 ; 33 (1S Suppl 1): e810-e817
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  • The natural history of COVID-19 in patients with inflammatory bowel disease: a nationwide study by the Hellenic Society for the study of IBD #MMPMID34402469
  • Bamias G; Kokkotis G; Christidou A; Christodoulou DK; Delis V; Diamantopoulou G; Fessatou S; Gatopoulou A; Giouleme O; Kafritsa P; Kalantzis C; Kapsoritakis A; Karatzas P; Karmiris K; Katsanos K; Kevrekidou P; Kosmidis C; Mantaka A; Mathou N; Michalopoulos G; Michopoulos S; Papaconstantinou I; Papatheodoridis G; Polymeros D; Potamianos S; Poulopoulos G; Protopapas A; Sklavaina M; Soufleris K; Theocharis G; Theodoropoulou A; Triantafillidis JK; Triantafyllou K; Tsiolakidou G; Tsironi E; Tzouvala M; Viazis N; Xourgias V; Zacharopoulou E; Zampeli E; Mantzaris GJ
  • Eur J Gastroenterol Hepatol 2021[Dec]; 33 (1S Suppl 1): e810-e817 PMID34402469show ga
  • OBJECTIVES: COVID-19 has evolved into a global health crisis, variably affecting the management of patients with chronic illnesses. Patients with inflammatory bowel disease (IBD) may represent a vulnerable population due to frequent administration of immune-modifying treatments. We aimed to depict the natural history of COVID-19 infection in Greek patients with IBD at a nationwide level via unbiased reporting of all cases that were registered during the sequential waves of the pandemic. METHODS: Following a national call from the Hellenic Society for the study of IBD, we enrolled all IBD patients with established diagnoses of COVID-19. Clinical and epidemiological data, including COVID-19 modifying factors and IBD-associated therapies, were analyzed against adverse outcomes (hospitalization, ICU admission and death). RESULTS: We identified 154 IBD patients who were diagnosed with COVID-19 (men: 58.4%; mean age=41.7 years [SD = 14.9]; CD: 64.3%). Adverse outcomes were reported in 34 patients (22.1%), including 3 ICU admissions (1.9%) and two deaths (1.3%). Multivariate logistic regression analysis showed that age (OR = 1.04, 95% CI, 1-1.08) and dyspnea at presentation (OR = 7.36, 95% CI, 1.84-29.46) were associated with worse outcomes of COVID-19 infection. In contrast, treatment with biologics, in particular anti-TNF agents, exerted a protective effect against an unfavorable COVID-19 disease course (OR = 0.4, 95% CI, 0.16-0.99). Patients on subcutaneous biologics were more likely to halt treatment due to the infection as compared to those on intravenous biologics. CONCLUSIONS: IBD patients who developed COVID-19 had a benign course with adverse outcomes being infrequent. Treatment with anti-TNF biologics had a protective effect, thus, supporting continuation of therapy during the pandemic.
  • |*COVID-19[MESH]
  • |*Inflammatory Bowel Diseases/drug therapy/epidemiology[MESH]
  • |Adult[MESH]
  • |Chronic Disease[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |SARS-CoV-2[MESH]


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