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10.1016/j.ahj.2021.08.001

http://scihub22266oqcxt.onion/10.1016/j.ahj.2021.08.001
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suck abstract from ncbi


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pmid34400140      Am+Heart+J 2021 ; 242 (ä): 61-70
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  • Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity #MMPMID34400140
  • Myhre PL; Heck SL; Skranes JB; Prebensen C; Jonassen CM; Berge T; Mecinaj A; Melles W; Einvik G; Ingul CB; Tveit A; Berdal JE; Rosjo H; Lyngbakken MN; Omland T
  • Am Heart J 2021[Dec]; 242 (ä): 61-70 PMID34400140show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) may cause myocardial injury and myocarditis, and reports of persistent cardiac pathology after COVID-19 have raised concerns of long-term cardiac consequences. We aimed to assess the presence of abnormal cardiovascular resonance imaging (CMR) findings in patients recovered from moderate-to-severe COVID-19, and its association with markers of disease severity in the acute phase. METHODS: Fifty-eight (49%) survivors from the prospective COVID MECH study, underwent CMR median 175 [IQR 105-217] days after COVID-19 hospitalization. Abnormal CMR was defined as left ventricular ejection fraction (LVEF) <50% or myocardial scar by late gadolinium enhancement. CMR indices were compared to healthy controls (n = 32), and to circulating biomarkers measured during the index hospitalization. RESULTS: Abnormal CMR was present in 12 (21%) patients, of whom 3 were classified with major pathology (scar and LVEF <50% or LVEF <40%). There was no difference in the need of mechanical ventilation, length of hospital stay, and vital signs between patients with vs without abnormal CMR after 6 months. Severe acute respiratory syndrome coronavirus 2 viremia and concentrations of inflammatory biomarkers during the index hospitalization were not associated with persistent CMR pathology. Cardiac troponin T and N-terminal pro-B-type natriuretic peptide concentrations on admission, were higher in patients with CMR pathology, but these associations were not significant after adjusting for demographics and established cardiovascular disease. CONCLUSIONS: CMR pathology 6 months after moderate-to-severe COVID-19 was present in 21% of patients and did not correlate with severity of the disease. Cardiovascular biomarkers during COVID-19 were higher in patients with CMR pathology, but with no significant association after adjusting for confounders. TRIAL REGISTRATION: COVID MECH Study ClinicalTrials.gov Identifier: NCT04314232.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/blood/*complications[MESH]
  • |Cicatrix/*diagnostic imaging/etiology[MESH]
  • |Female[MESH]
  • |Gadolinium[MESH]
  • |Heart Diseases/blood/*diagnostic imaging/etiology/physiopathology[MESH]
  • |Humans[MESH]
  • |Magnetic Resonance Imaging, Cine/*methods[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Natriuretic Peptide, Brain/blood[MESH]
  • |Peptide Fragments/blood[MESH]
  • |Prospective Studies[MESH]
  • |Severity of Illness Index[MESH]
  • |Stroke Volume[MESH]
  • |Survivors[MESH]
  • |Troponin T/blood[MESH]


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