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10.1186/s12935-021-02129-x

http://scihub22266oqcxt.onion/10.1186/s12935-021-02129-x
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34399734!8365127!34399734
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suck abstract from ncbi


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pmid34399734      Cancer+Cell+Int 2021 ; 21 (1): 431
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  • Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19 #MMPMID34399734
  • Shafiee S; Cegolon L; Khafaei M; Gholami N; Zhao S; Khalesi N; Moosavian H; Fathi S; Izadi M; Ghadian A; Javanbakht M; Javanbakht A; Akhavan-Sigari R
  • Cancer Cell Int 2021[Aug]; 21 (1): 431 PMID34399734show ga
  • Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRSS2 can be altered in malignancies. Shedding light on this matter could be crucial since the COVID-19 pandemic interfered with many gastrointestinal cancer screening programs. Herein we discuss the possibility of severe forms of COVID-19 in patients with gastrointestinal cancers due to the gastrointestinal entry route of SARS-CoV-2 into the human body. The disruption of cancer screening programs caused by the current COVID-19 pandemic could therefore have massive negative health impact on patients affected by gastrointestinal malignancies.
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