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10.2174/1566524021666210816095557

http://scihub22266oqcxt.onion/10.2174/1566524021666210816095557
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34397331!ä!34397331

suck abstract from ncbi


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pmid34397331      Curr+Mol+Med 2022 ; 22 (6): 471-477
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  • Low pH and Temperature of Airway Surface Liquid are Key Determinants that Potentiate SARS-CoV-2 Infectivity #MMPMID34397331
  • Sharma NK; Sarode SC
  • Curr Mol Med 2022[]; 22 (6): 471-477 PMID34397331show ga
  • Overwhelming responses are seen at preclinical and clinical levels to understand and combat coronavirus disease 2019 [COVID-19] pandemic that is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]. Encouraging successes are achieved in view of diagnostic, therapeutic and preventive measures, including vaccines development. In fact, structural information of SARS-CoV-2 and molecular steps that help this virus target AECs are appreciably studied. Furthermore, the heterogeneous and complex nature of COVID-19 is extensively revealed at molecular, genetic, and epigenetic and microenvironment levels. In spite of these developments in COVID-19 pathogenesis, the reasons behind the targeted infection by SARS-CoV-2 to AECs are poorly understood. In this mini-review, we highlight the roles of pH and temperature of airway surface liquid [ASL] as a key determining factor that may contribute towards enhanced targeted infection by SARS-CoV-2 leading to COVID- 19.
  • |*COVID-19[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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