Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1093/nar/gkab701

http://scihub22266oqcxt.onion/10.1093/nar/gkab701
suck pdf from google scholar
34396391!8385993!34396391
unlimited free pdf from europmc34396391    free
PDF from PMC    free
html from PMC    free
PDF vom PMID34396391  :  Publisher

suck abstract from ncbi

pmid34396391
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations #MMPMID34396391
  • Nersisyan S; Zhiyanov A; Shkurnikov M; Tonevitsky A
  • Nucleic Acids Res 2022[Jan]; 50 (D1): D883-D887 PMID34396391show ga
  • Rapidly appearing SARS-CoV-2 mutations can affect T cell epitopes, which can help the virus to evade either CD8 or CD4 T-cell responses. We developed T-cell COVID-19 Atlas (T-CoV, https://t-cov.hse.ru) - the comprehensive web portal, which allows one to analyze how SARS-CoV-2 mutations alter the presentation of viral peptides by HLA molecules. The data are presented for common virus variants and the most frequent HLA class I and class II alleles. Binding affinities of HLA molecules and viral peptides were assessed with accurate in silico methods. The obtained results highlight the importance of taking HLA alleles diversity into account: mutation-mediated alterations in HLA-peptide interactions were highly dependent on HLA alleles. For example, we found that the essential number of peptides tightly bound to HLA-B*07:02 in the reference Wuhan variant ceased to be tight binders for the Indian (Delta) and the UK (Alpha) variants. In summary, we believe that T-CoV will help researchers and clinicians to predict the susceptibility of individuals with different HLA genotypes to infection with variants of SARS-CoV-2 and/or forecast its severity.
  • |*Databases, Factual[MESH]
  • |Alleles[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Codon, Terminator[MESH]
  • |Epitopes, T-Lymphocyte/immunology[MESH]
  • |HLA Antigens/genetics/immunology/*metabolism[MESH]
  • |HLA-B7 Antigen/immunology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |India[MESH]
  • |Mutation[MESH]
  • |SARS-CoV-2/*genetics/pathogenicity[MESH]
  • |United Kingdom[MESH]
  • |Viral Proteins/genetics/immunology[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    D883 D1.50 2022