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10.1016/j.comptc.2021.113392 http://scihub22266oqcxt.onion/10.1016/j.comptc.2021.113392 34395179!8351912!34395179     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Theor+Chem 2021 ; 1204 (ä): 113392 Nephropedia Template TP {{tp|p=34395179|t=2021. SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations |pdf=|usr=}}{{34395179}} gab.com Text SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations JO: Comput Theor Chem http://www.kidney.de/pget.php?&tw=1&pmid=34395179 #FOAvip The trimeric spike (S) glycoprotein is the trojan horse and the stronghold of the severe acute respiratory syndrome coronaviruses. Although several structures of the S-protein have been solved, a complete understanding of all its functions is still lacking. Our multi-approach study, based on the combination of structural experimental data and quantum-chemical DFT calculations, led to identify a sequestration site for sodium, potassium and chloride ions within the central cavity of both the SARS-CoV-1 and SARS-CoV-2 spike proteins. The same region was found as strictly conserved, even among the sequences of the bat-respective coronaviruses. Due to the prominent role of the main three electrolytes at many levels, and their possible implication in the molecular mechanisms of COVID-19 disease, our study can take the lead in important discoveries related to the SARS-CoV-2 biology, as well as in the design of novel effective therapeutic strategies. Twit Text FOAVip SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations ????Comput Theor Chem http://www.kidney.de/pget.php?&tw=1&pmid=34395179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34395179 #FOAvip English Wikipedia <ref>{{Cite pmid|34395179}}</ref> SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations #MMPMID34395179 Margiotta E; Fonseca Guerra C Comput Theor Chem 2021[Oct]; 1204 (ä): 113392 PMID34395179show ga The trimeric spike (S) glycoprotein is the trojan horse and the stronghold of the severe acute respiratory syndrome coronaviruses. Although several structures of the S-protein have been solved, a complete understanding of all its functions is still lacking. Our multi-approach study, based on the combination of structural experimental data and quantum-chemical DFT calculations, led to identify a sequestration site for sodium, potassium and chloride ions within the central cavity of both the SARS-CoV-1 and SARS-CoV-2 spike proteins. The same region was found as strictly conserved, even among the sequences of the bat-respective coronaviruses. Due to the prominent role of the main three electrolytes at many levels, and their possible implication in the molecular mechanisms of COVID-19 disease, our study can take the lead in important discoveries related to the SARS-CoV-2 biology, as well as in the design of novel effective therapeutic strategies. äSARS-CoV spike proteins can compete for electrolytes in physiological (epmc).pdf DeepDyve Pubget Overpricing