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10.1016/j.clml.2021.07.004

http://scihub22266oqcxt.onion/10.1016/j.clml.2021.07.004
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34393077!8286809!34393077
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suck abstract from ncbi


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pmid34393077      Clin+Lymphoma+Myeloma+Leuk 2021 ; 21 (10): e810-e816
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  • Resolution of One-Year Persisting COVID-19 Pneumonia and Development of Immune Thrombocytopenia in a Follicular Lymphoma Patient With Preceding Rituximab Maintenance Therapy: A follow-up Report and Literature Review of Cases With Prolonged Infections #MMPMID34393077
  • Yasuda H; Mori Y; Chiba A; Bai J; Murayama G; Matsushita Y; Miyake S; Komatsu N
  • Clin Lymphoma Myeloma Leuk 2021[Oct]; 21 (10): e810-e816 PMID34393077show ga
  • BACKGROUND: We previously reported elsewhere of a follicular lymphoma patient suffering from persistent COVID-19 pneumonia that was still ongoing at 2 months after onset. MATERIALS AND METHODS: We provide a follow-up report of the case along with a literature review of immunocompromised lymphoma patients experiencing prolonged COVID-19 infections. RESULTS: Although requiring a full 1 year, the presented case eventually achieved spontaneous resolution of COVID-19 pneumonia. Anti-SARS-CoV-2 antibodies could not be detected throughout the disease course, but COVID-19-directed T-cell response was found to be intact. The patient also developed secondary immune thrombocytopenia subsequent to COVID-19 pneumonia. We found 19 case reports of immunocompromised lymphoma patients with prolonged COVID-19 infections in the literature. All 5 patients who died did not receive convalescent plasma therapy, whereas resolution of COVID-19 infection was achieved in 8 out of 9 patients who received convalescent plasma therapy. CONCLUSIONS: We demonstrate through the presented case that while time-consuming, resolution of COVID-19 infections may be achieved without aid from humoral immunity if cellular immunity is intact. Immunocompromised lymphoma patients are at risk of a prolonged disease course of COVID-19, and convalescent plasma therapy may be a promising approach in such patients.
  • |Antineoplastic Agents, Immunological/therapeutic use[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host/immunology[MESH]
  • |Lymphoma, Follicular/complications/*drug therapy/immunology[MESH]
  • |Maintenance Chemotherapy/methods[MESH]
  • |Middle Aged[MESH]
  • |Pneumonia/complications/*immunology/virology[MESH]
  • |Remission, Spontaneous[MESH]
  • |Rituximab/*therapeutic use[MESH]
  • |SARS-CoV-2/*immunology/physiology[MESH]
  • |T-Lymphocytes/immunology/virology[MESH]


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