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10.4049/jimmunol.2100465 http://scihub22266oqcxt.onion/10.4049/jimmunol.2100465 34389625!8763019!34389625     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34389625&cmd=llinks): Failed to open stream: HTTP request failed! 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Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8(+) T Cells during Convalescence |pdf=|usr=}}{{34389625}} gab.com Text Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8(+) T Cells during Convalescence JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34389625 #FOAvip CD8(+) T cells can potentiate long-lived immunity against COVID-19. We screened longitudinally-sampled convalescent human donors against SARS-CoV-2 tetramers and identified a participant with an immunodominant response against residues 322 to 311 of nucleocapsid (Nuc(322-331)), a peptide conserved in all variants of concern reported to date. We conducted 38-parameter cytometry by time of flight on tetramer-identified Nuc(322-331)-specific CD8(+) T cells and on CD4(+) and CD8(+) T cells recognizing the entire nucleocapsid and spike proteins, and took 32 serological measurements. We discovered a coordination of the Nuc(322-331)-specific CD8(+) T response with both the CD4(+) T cell and Ab pillars of adaptive immunity. Over the approximately six month period of convalescence monitored, we observed a slow and progressive decrease in the activation state and polyfunctionality of Nuc(322-331)-specific CD8(+) T cells, accompanied by an increase in their lymph node-homing and homeostatic proliferation potential. These results suggest that following a typical case of mild COVID-19, SARS-CoV-2-specific CD8(+) T cells not only persist but continuously differentiate in a coordinated fashion well into convalescence into a state characteristic of long-lived, self-renewing memory. Twit Text FOAVip Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8(+) T Cells during Convalescence ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34389625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34389625 #FOAvip English Wikipedia <ref>{{Cite pmid|34389625}}</ref> Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8(+) T Cells during Convalescence #MMPMID34389625 Ma T; Ryu H; McGregor M; Babcock B; Neidleman J; Xie G; George AF; Frouard J; Murray V; Gill G; Ghosn E; Newell EW; Lee SA; Roan NR J Immunol 2021[Sep]; 207 (5): 1344-1356 PMID34389625show ga CD8(+) T cells can potentiate long-lived immunity against COVID-19. We screened longitudinally-sampled convalescent human donors against SARS-CoV-2 tetramers and identified a participant with an immunodominant response against residues 322 to 311 of nucleocapsid (Nuc(322-331)), a peptide conserved in all variants of concern reported to date. We conducted 38-parameter cytometry by time of flight on tetramer-identified Nuc(322-331)-specific CD8(+) T cells and on CD4(+) and CD8(+) T cells recognizing the entire nucleocapsid and spike proteins, and took 32 serological measurements. We discovered a coordination of the Nuc(322-331)-specific CD8(+) T response with both the CD4(+) T cell and Ab pillars of adaptive immunity. Over the approximately six month period of convalescence monitored, we observed a slow and progressive decrease in the activation state and polyfunctionality of Nuc(322-331)-specific CD8(+) T cells, accompanied by an increase in their lymph node-homing and homeostatic proliferation potential. These results suggest that following a typical case of mild COVID-19, SARS-CoV-2-specific CD8(+) T cells not only persist but continuously differentiate in a coordinated fashion well into convalescence into a state characteristic of long-lived, self-renewing memory. |*Convalescence[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |COVID-19/*immunology[MESH] |Humans[MESH] |Longitudinal Studies[MESH]Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Sp(epmc).pdf DeepDyve Pubget Overpricing