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10.1055/s-0041-1733934 http://scihub22266oqcxt.onion/10.1055/s-0041-1733934 34388849!ä!34388849 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34388849&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 221.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 221.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 221.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 221.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 221.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 221.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thromb+Haemost 2022 ; 122 (10): 1706-1711 Nephropedia Template TP {{tp|p=34388849|t=2022. Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination |pdf=|usr=}}{{34388849}} gab.com Text Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination JO: Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=34388849 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a coagulopathy characterized by platelet activation and a hypercoagulable state with an increased incidence of cardiovascular events. The viral spike protein S has been reported to enhance thrombosis formation, stimulate platelets to release procoagulant factors, and promote the formation of platelet-leukocyte aggregates even in absence of the virus. Although SARS-CoV-2 vaccines induce spike protein overexpression to trigger SARS-CoV-2-specific immune protection, thrombocyte activity has not been investigated in this context. Here, we provide the first phenotypic platelet characterization of healthy human subjects undergoing BNT162b2 vaccination. Using mass cytometry, we analyzed the expression of constitutive transmembrane receptors, adhesion proteins, and platelet activation markers in 12 healthy donors before and at five different time points within 4 weeks after the first BNT162b2 administration. We measured platelet reactivity by stimulating thrombocyte activation with thrombin receptor-activating peptide. Activation marker expression (P-selectin, LAMP-3, LAMP-1, CD40L, and PAC-1) did not change after vaccination. All investigated constitutive transmembrane proteins showed similar expressions over time. Platelet reactivity was not altered after BNT162b2 administration. Activation marker expression was significantly lower compared with an independent cohort of mild symptomatic COVID-19 patients analyzed with the same platform. This study reveals that BNT162b2 administration does not alter platelet protein expression and reactivity. Twit Text FOAVip Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination ????Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=34388849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34388849 #FOAvip English Wikipedia <ref>{{Cite pmid|34388849}}</ref> Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination #MMPMID34388849 Klug M; Lazareva O; Kirmes K; Rosenbaum M; Lukas M; Weidlich S; Spinner CD; von Scheidt M; Gosetti R; Baumbach J; Ruland J; Condorelli G; Laugwitz KL; List M; Bernlochner I; Bongiovanni D Thromb Haemost 2022[Oct]; 122 (10): 1706-1711 PMID34388849show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a coagulopathy characterized by platelet activation and a hypercoagulable state with an increased incidence of cardiovascular events. The viral spike protein S has been reported to enhance thrombosis formation, stimulate platelets to release procoagulant factors, and promote the formation of platelet-leukocyte aggregates even in absence of the virus. Although SARS-CoV-2 vaccines induce spike protein overexpression to trigger SARS-CoV-2-specific immune protection, thrombocyte activity has not been investigated in this context. Here, we provide the first phenotypic platelet characterization of healthy human subjects undergoing BNT162b2 vaccination. Using mass cytometry, we analyzed the expression of constitutive transmembrane receptors, adhesion proteins, and platelet activation markers in 12 healthy donors before and at five different time points within 4 weeks after the first BNT162b2 administration. We measured platelet reactivity by stimulating thrombocyte activation with thrombin receptor-activating peptide. Activation marker expression (P-selectin, LAMP-3, LAMP-1, CD40L, and PAC-1) did not change after vaccination. All investigated constitutive transmembrane proteins showed similar expressions over time. Platelet reactivity was not altered after BNT162b2 administration. Activation marker expression was significantly lower compared with an independent cohort of mild symptomatic COVID-19 patients analyzed with the same platform. This study reveals that BNT162b2 administration does not alter platelet protein expression and reactivity. |*BNT162 Vaccine/adverse effects[MESH] |*Blood Platelets/metabolism[MESH] |*COVID-19/prevention & control[MESH] |Antibodies, Viral[MESH] |CD40 Ligand[MESH] |COVID-19 Vaccines/adverse effects[MESH] |Humans[MESH] |Membrane Proteins/metabolism[MESH] |P-Selectin/metabolism[MESH] |Receptors, Thrombin/metabolism[MESH] |SARS-CoV-2[MESH]Platelet Surface Protein Expression and Reactivity upon TRAP Stimulati(epmc).pdf DeepDyve Pubget Overpricing