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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Chem+Lab+Med 2021 ; 59 (12): 1998-2002 Nephropedia Template TP
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Alternative detection of SARS-CoV-2 RNA by a new assay based on mass spectrometry #MMPMID34388325
Stelzl E; Kessler HH; Mustafa HG; Mustafa ME; Santner BI; Seier J; La Torre M; Haushofer AC
Clin Chem Lab Med 2021[Nov]; 59 (12): 1998-2002 PMID34388325show ga
OBJECTIVES: Accurate detection of SARS-CoV-2 RNA is essential to stopping the spread of SARS-CoV-2. The aim of this study was to evaluate the performance of the recently introduced MassARRAY((R)) SARS-CoV-2 Panel and to compare it to the cobas((R)) SARS-CoV-2 Test. METHODS: The MassARRAY((R)) SARS-CoV-2 Panel consists of five assays targeting different sequences of the SARS-CoV-2 genome. Accuracy was determined using national and international proficiency panels including 27 samples. For clinical evaluation, 101 residual clinical samples were analyzed and results compared. Samples had been tested for SARS-CoV-2 RNA with the cobas((R)) SARS-CoV-2 Test. RESULTS: When accuracy was tested with the MassARRAY((R)) SARS-CoV-2 Panel, 25 of 27 (92.6%) samples revealed correct results. When clinical samples were analyzed with the MassARRAY((R)) SARS-CoV-2 Panel and compared to the cobas((R)) SARS-CoV-2 Test, 100 samples showed concordant results. One sample was found to be inconclusive with the MassARRAY((R)) SARS-CoV-2 Panel. When time-to-results were compared, the new assay showed longer total and hands-on times. CONCLUSIONS: The MassARRAY((R)) SARS-CoV-2 Panel showed a good performance and proved to be suitable for use in the routine diagnostic laboratory. Especially during phases of shortage of reagents and/or disposables, the new test system appears as beneficial alternative to standard assays used for detection of SARS-CoV-2 RNA.