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10.17116/jnevro202112107231

http://scihub22266oqcxt.onion/10.17116/jnevro202112107231
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34387443!ä!34387443

suck abstract from ncbi


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pmid34387443      Zh+Nevrol+Psikhiatr+Im+S+S+Korsakova 2021 ; 121 (7. Vyp. 2): 31-36
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  • Terapiya monoklonal'nymi antitelami bystroprogressiruyushchego i vysokoaktivnogo rasseyannogo skleroza v epokhu pandemii COVID-19 #MMPMID34387443
  • Eliseeva DD; Vasiliev AV; Abramova AA; Kochergin IA; Zakharova MN
  • Zh Nevrol Psikhiatr Im S S Korsakova 2021[]; 121 (7. Vyp. 2): 31-36 PMID34387443show ga
  • As the COVID-19 pandemic continues, reducing the risk of infection for immunocompromised patients remains an important issue. Patients with aggressive multiple sclerosis (MS) require immunosuppressive therapy in order to control the overactive autoimmune response. Preliminary international and national trials demonstrate that older age, higher disability status and progressive MS are generally associated with a more severe clinical course of COVID-19. However, uncertainty remains about the effect of disease-modifying therapies on the COVID-19 clinical presentation. In this article, we pay special attention to monoclonal antibodies used for immune reconstitution therapy, which results in significant changes to the T-cell and/or B-cell repertoire. Based on the published data from registries in different countries, we attempted to estimate the benefits and risks of these therapies in a complicated epidemiological setting.
  • |*COVID-19[MESH]
  • |*Multiple Sclerosis/drug therapy/epidemiology[MESH]
  • |Aged[MESH]
  • |Antibodies, Monoclonal/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Pandemics[MESH]


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