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10.1042/ETLS20210127 http://scihub22266oqcxt.onion/10.1042/ETLS20210127 34387325!ä!34387325 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Top+Life+Sci 2021 ; 5 (5): 597-600 Nephropedia Template TP {{tp|p=34387325|t=2021. ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics |pdf=|usr=}}{{34387325}} gab.com Text ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics JO: Emerg Top Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=34387325 #FOAvip In recent months as vaccines against the SARS-CoV-2 virus continue to rollout across the globe, there has been a renewed interest in ways to activate or ignite the immune system. For a vaccine to be effective, it must be immunogenic and specific to provoke the body's defenses to mount an effective response that protects the host from disease. However, there are other situations wherein the immune system mounts an unwanted immune response that can be detrimental to health, either directly, by causing an autoimmune disease, or indirectly, by compromising the safety and/or efficacy of biologic drugs. In these scenarios, it would be desirable to have a 'tolerogenic vaccine' that could selectively and effectively mitigate these unwanted immune responses. ImmTORTM, a nanoparticle technology, is being developed to address the issue of immunogenicity for gene therapy vectors and other biologic drugs. By targeting antigen-presenting cells, ImmTORTM has the potential to amplify the efficacy of biologic therapies and unlock the full potential of such treatments to improve the lives of those who suffer from serious and debilitating diseases. Twit Text FOAVip ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics ????Emerg Top Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=34387325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34387325 #FOAvip English Wikipedia <ref>{{Cite pmid|34387325}}</ref> ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics #MMPMID34387325 Brunn C; Kishimoto TK Emerg Top Life Sci 2021[Nov]; 5 (5): 597-600 PMID34387325show ga In recent months as vaccines against the SARS-CoV-2 virus continue to rollout across the globe, there has been a renewed interest in ways to activate or ignite the immune system. For a vaccine to be effective, it must be immunogenic and specific to provoke the body's defenses to mount an effective response that protects the host from disease. However, there are other situations wherein the immune system mounts an unwanted immune response that can be detrimental to health, either directly, by causing an autoimmune disease, or indirectly, by compromising the safety and/or efficacy of biologic drugs. In these scenarios, it would be desirable to have a 'tolerogenic vaccine' that could selectively and effectively mitigate these unwanted immune responses. ImmTORTM, a nanoparticle technology, is being developed to address the issue of immunogenicity for gene therapy vectors and other biologic drugs. By targeting antigen-presenting cells, ImmTORTM has the potential to amplify the efficacy of biologic therapies and unlock the full potential of such treatments to improve the lives of those who suffer from serious and debilitating diseases. |*Autoimmune Diseases[MESH] |*Biological Products/therapeutic use[MESH] |*COVID-19[MESH] |*Vaccines[MESH] |Humans[MESH]ImmTORTM to amplify the efficacy and reduce immunogenicity of biologic(epmc).pdf DeepDyve Pubget Overpricing