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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Leuk+Lymphoma 2021 ; 62 (14): 3516-3520 Nephropedia Template TP
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Acute leukemia and SARS-CoV-2 infection: clinical characteristics and risk factors for mortality #MMPMID34387145
Mitrovic M; Pantic N; Sabljic N; Vucic M; Bukumiric Z; Virijevic M; Pravdic Z; Rajic J; Todorovic-Balint M; Vidovic A; Suvajdzic-Vukovic N
Leuk Lymphoma 2021[Dec]; 62 (14): 3516-3520 PMID34387145show ga
Patients with acute leukemia (AL) have a high mortality rate from coronavirus disease 2019 (COVID-19). However, studies including patients with AL and COVID-19 are few. Fifty-one patients with AL and COVID-19 were included in our study. The mortality rate was 17/51 (29.4%). In all cases, death was associated with COVID-19 pneumonia. The major driver of outcome was the disease status (worse outcome was observed in newly diagnosed (OR, 6.00; 95% CI, 1.133 - 15.188) and patients with bone marrow aplasia (OR 4.148 [95% CI 1.133 - 15.188])). Higher mortality rate was associated with lower platelet count, prolonged PT, higher ISTH DIC score, CRP and LDH. Moreover, careful risk-benefit assessment regarding the continuation of anticancer therapy is required in patients receiving nonintensive and supportive therapy. Considering the high frequency of intrahospital viral transmission (50.98%), isolation of AL patients in single rooms, and permanent symptom monitoring and testing should be prioritized.