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Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cardiovasc+Endocrinol+Metab 2021 ; 10 (3): 162-167 Nephropedia Template TP
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Salivary markers and coronavirus disease 2019: insights from cross-talk between the oral microbiome and pulmonary and systemic low-grade inflammation and implications for vascular complications #MMPMID34386717
AbdelMassih A; Hassan AA; Abou-Zeid AS; Hassan A; Hussein E; Gadalla M; Hussein M; Eid MA; Elahmady M; El Nahhas N; Emad N; Zahra N; Aboushadi N; Ibrahim N; Mokhtar S; Ismail HA; El-Husseiny N; Moharam RK; Menshawey E; Menshawey R
Cardiovasc Endocrinol Metab 2021[Sep]; 10 (3): 162-167 PMID34386717show ga
To date, coronavirus disease 2019 (COVID-19) has affected over 6.2 million individuals worldwide, including 1.46 million deaths. COVID-19 complications are mainly induced by low-grade inflammation-causing vascular degeneration. There is an increasing body of evidence that suggests that oral dysbiotic taxa are associated with worse prognosis in COVID-19 patients, especially the Prevotella genus, which was retrieved from nasopharyngeal and bronchoalveolar lavage samples in affected patients. Oral dysbiosis may act by increasing the likelihood of vascular complications through low-grade inflammation, as well as impairing respiratory mucosal barrier mechanisms against SARS-CoV-2. Salivary markers can be used to reflect this oral dysbiosis and its subsequent damaging effects on and the lungs and vasculature. Salivary sampling can be self-collected, and is less costly and less invasive, and thus may be a superior option to serum markers in risk stratification of COVID-19 patients. Prospective studies are needed to confirm such hypothesis. Video Abstract: http://links.lww.com/CAEN/A28.