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10.3389/fbioe.2021.718753 http://scihub22266oqcxt.onion/10.3389/fbioe.2021.718753 34386486!8354200!34386486     free     free     free       Front+Bioeng+Biotechnol 2021 ; 9 (ä): 718753 Nephropedia Template TP {{tp|p=34386486|t=2021. Development and Delivery Systems of mRNA Vaccines |pdf=|usr=}}{{34386486}} gab.com Text Development and Delivery Systems of mRNA Vaccines JO: Front Bioeng Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34386486 #FOAvip Since the outbreak of SARS-CoV-2, mRNA vaccine development has undergone a tremendous drive within the pharmaceutical field. In recent years, great progress has been made into mRNA vaccine development, especially in individualized tumor vaccines. mRNA vaccines are a promising approach as the production process is simple, safety profiles are better than those of DNA vaccines, and mRNA-encoded antigens are readily expressed in cells. However, mRNA vaccines also possess some inherent limitations. While side effects such as allergy, renal failure, heart failure, and infarction remain a risk, the vaccine mRNA may also be degraded quickly after administration or cause cytokine storms. This is a substantial challenge for mRNA delivery. However, appropriate carriers can avoid degradation and enhance immune responses, effector presentation, biocompatibility and biosafety. To understand the development and research status of mRNA vaccines, this review focuses on analysis of molecular design, delivery systems and clinical trials of mRNA vaccines, thus highlighting the route for wider development and further clinical trials of mRNA vaccines. Twit Text FOAVip Development and Delivery Systems of mRNA Vaccines ????Front Bioeng Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34386486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34386486 #FOAvip English Wikipedia <ref>{{Cite pmid|34386486}}</ref> Development and Delivery Systems of mRNA Vaccines #MMPMID34386486 Liu T; Liang Y; Huang L Front Bioeng Biotechnol 2021[]; 9 (ä): 718753 PMID34386486show ga Since the outbreak of SARS-CoV-2, mRNA vaccine development has undergone a tremendous drive within the pharmaceutical field. In recent years, great progress has been made into mRNA vaccine development, especially in individualized tumor vaccines. mRNA vaccines are a promising approach as the production process is simple, safety profiles are better than those of DNA vaccines, and mRNA-encoded antigens are readily expressed in cells. However, mRNA vaccines also possess some inherent limitations. While side effects such as allergy, renal failure, heart failure, and infarction remain a risk, the vaccine mRNA may also be degraded quickly after administration or cause cytokine storms. This is a substantial challenge for mRNA delivery. However, appropriate carriers can avoid degradation and enhance immune responses, effector presentation, biocompatibility and biosafety. To understand the development and research status of mRNA vaccines, this review focuses on analysis of molecular design, delivery systems and clinical trials of mRNA vaccines, thus highlighting the route for wider development and further clinical trials of mRNA vaccines. äDevelopment and Delivery Systems of mRNA Vaccines (epmc).pdf DeepDyve Pubget Overpricing