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10.5415/apallergy.2021.11.e30 http://scihub22266oqcxt.onion/10.5415/apallergy.2021.11.e30 34386406!8331253!34386406     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Asia+Pac+Allergy 2021 ; 11 (3): e30 Nephropedia Template TP {{tp|p=34386406|t=2021. Eosinophil-mediated inflammation in the absence of eosinophilia |pdf=|usr=}}{{34386406}} gab.com Text Eosinophil-mediated inflammation in the absence of eosinophilia JO: Asia Pac Allergy http://www.kidney.de/pget.php?&tw=1&pmid=34386406 #FOAvip The increase of eosinophil levels is a hallmark of type-2 inflammation. Blood eosinophil counts act as a convenient biomarker for asthma phenotyping and the selection of biologics, and they are even used as a prognostic factor for severe coronavirus disease 2019. However, the circulating eosinophil count does not always reflect tissue eosinophilia and vice versa. The mismatch of blood and tissue eosinophilia can be seen in various clinical settings. For example, blood eosinophil levels in patients with acute eosinophilic pneumonia are often within normal range despite the marked symptoms and increased number of eosinophils in bronchoalveolar lavage fluid. Histological studies using immunostaining for eosinophil granule proteins have revealed the extracellular deposition of granule proteins coincident with pathological conditions, even in the absence of a significant eosinophil infiltrate. The marked deposition of eosinophil granule proteins in tissue is often associated with cytolytic degranulation. Recent studies have indicated that extracellular trap cell death (ETosis) is a major mechanism of cytolysis. Cytolytic ETosis is a total cell degranulation in which cytoplasmic and nuclear contents, including DNA and histones that act as alarmins, are also released. In the present review, eosinophil-mediated inflammation in such mismatch conditions is discussed. Twit Text FOAVip Eosinophil-mediated inflammation in the absence of eosinophilia ????Asia Pac Allergy http://www.kidney.de/pget.php?&tw=1&pmid=34386406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34386406 #FOAvip English Wikipedia <ref>{{Cite pmid|34386406}}</ref> Eosinophil-mediated inflammation in the absence of eosinophilia #MMPMID34386406 Miyabe Y; Kobayashi Y; Fukuchi M; Saga A; Moritoki Y; Saga T; Akuthota P; Ueki S Asia Pac Allergy 2021[Jul]; 11 (3): e30 PMID34386406show ga The increase of eosinophil levels is a hallmark of type-2 inflammation. Blood eosinophil counts act as a convenient biomarker for asthma phenotyping and the selection of biologics, and they are even used as a prognostic factor for severe coronavirus disease 2019. However, the circulating eosinophil count does not always reflect tissue eosinophilia and vice versa. The mismatch of blood and tissue eosinophilia can be seen in various clinical settings. For example, blood eosinophil levels in patients with acute eosinophilic pneumonia are often within normal range despite the marked symptoms and increased number of eosinophils in bronchoalveolar lavage fluid. Histological studies using immunostaining for eosinophil granule proteins have revealed the extracellular deposition of granule proteins coincident with pathological conditions, even in the absence of a significant eosinophil infiltrate. The marked deposition of eosinophil granule proteins in tissue is often associated with cytolytic degranulation. Recent studies have indicated that extracellular trap cell death (ETosis) is a major mechanism of cytolysis. Cytolytic ETosis is a total cell degranulation in which cytoplasmic and nuclear contents, including DNA and histones that act as alarmins, are also released. In the present review, eosinophil-mediated inflammation in such mismatch conditions is discussed. äEosinophil-mediated inflammation in the absence of eosinophilia (epmc).pdf DeepDyve Pubget Overpricing