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10.1038/s41419-021-03881-8

http://scihub22266oqcxt.onion/10.1038/s41419-021-03881-8
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suck abstract from ncbi


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pmid34385425      Cell+Death+Dis 2021 ; 12 (8): 788
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  • Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2-host interactome #MMPMID34385425
  • Messina F; Giombini E; Montaldo C; Sharma AA; Zoccoli A; Sekaly RP; Locatelli F; Zumla A; Maeurer M; Capobianchi MR; Lauria FN; Ippolito G
  • Cell Death Dis 2021[Aug]; 12 (8): 788 PMID34385425show ga
  • In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but the mechanisms of interaction between host and SARS-CoV-2, determining the grade of COVID-19 severity, are still unknown. We provide a network analysis on protein-protein interactions (PPI) between viral and host proteins to better identify host biological responses, induced by both whole proteome of SARS-CoV-2 and specific viral proteins. A host-virus interactome was inferred, applying an explorative algorithm (Random Walk with Restart, RWR) triggered by 28 proteins of SARS-CoV-2. The analysis of PPI allowed to estimate the distribution of SARS-CoV-2 proteins in the host cell. Interactome built around one single viral protein allowed to define a different response, underlining as ORF8 and ORF3a modulated cardiovascular diseases and pro-inflammatory pathways, respectively. Finally, the network-based approach highlighted a possible direct action of ORF3a and NS7b to enhancing Bradykinin Storm. This network-based representation of SARS-CoV-2 infection could be a framework for pathogenic evaluation of specific clinical outcomes. We identified possible host responses induced by specific proteins of SARS-CoV-2, underlining the important role of specific viral accessory proteins in pathogenic phenotypes of severe COVID-19 patients.
  • |COVID-19/*metabolism/*virology[MESH]
  • |Host Microbial Interactions[MESH]
  • |Immunity/immunology[MESH]
  • |Protein Interaction Maps/physiology[MESH]
  • |Proteome[MESH]
  • |Proteomics/methods[MESH]
  • |SARS-CoV-2/*metabolism/pathogenicity[MESH]
  • |Severity of Illness Index[MESH]
  • |Viral Proteins/metabolism[MESH]


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