Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34385356&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants #MMPMID34385356
Pegu A; O'Connell SE; Schmidt SD; O'Dell S; Talana CA; Lai L; Albert J; Anderson E; Bennett H; Corbett KS; Flach B; Jackson L; Leav B; Ledgerwood JE; Luke CJ; Makowski M; Nason MC; Roberts PC; Roederer M; Rebolledo PA; Rostad CA; Rouphael NG; Shi W; Wang L; Widge AT; Yang ES; Beigel JH; Graham BS; Mascola JR; Suthar MS; McDermott AB; Doria-Rose NA; Arega J; Beigel JH; Buchanan W; Elsafy M; Hoang B; Lampley R; Kolhekar A; Koo H; Luke C; Makhene M; Nayak S; Pikaart-Tautges R; Roberts PC; Russell J; Sindall E; Albert J; Kunwar P; Makowski M; Anderson EJ; Bechnak A; Bower M; Camacho-Gonzalez AF; Collins M; Drobeniuc A; Edara VV; Edupuganti S; Floyd K; Gibson T; Ackerley CMG; Johnson B; Kamidani S; Kao C; Kelley C; Lai L; Macenczak H; McCullough MP; Peters E; Phadke VK; Rebolledo PA; Rostad CA; Rouphael N; Scherer E; Sherman A; Stephens K; Suthar MS; Teherani M; Traenkner J; Winston J; Yildirim I; Barr L; Benoit J; Carste B; Choe J; Dunstan M; Erolin R; Ffitch J; Fields C; Jackson LA; Kiniry E; Lasicka S; Lee S; Nguyen M; Pimienta S; Suyehira J; Witte M; Bennett H; Altaras NE; Carfi A; Hurley M; Leav B; Pajon R; Sun W; Zaks T; Coler RN; Larsen SE; Neuzil KM; Lindesmith LC; Martinez DR; Munt J; Mallory M; Edwards C; Baric RS; Berkowitz NM; Boritz EA; Carlton K; Corbett KS; Costner P; Creanga A; Doria-Rose NA; Douek DC; Flach B; Gaudinski M; Gordon I; Graham BS; Holman L; Ledgerwood JE; Leung K; Lin BC; Louder MK; Mascola JR; McDermott AB; Morabito KM; Novik L; O'Connell S; O'Dell S; Padilla M; Pegu A; Schmidt SD; Shi W; Swanson PA 2nd; Talana CA; Wang L; Widge AT; Yang ES; Zhang Y; Chappell JD; Denison MR; Hughes T; Lu X; Pruijssers AJ; Stevens LJ; Posavad CM; Gale M Jr; Menachery V; Shi PY
Science 2021[Sep]; 373 (6561): 1372-1377 PMID34385356show ga
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the effect of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, and angiotensin-converting enzyme 2 (ACE2)-competing antibodies elicited by the messenger RNA (mRNA) vaccine mRNA-1273 over 7 months. Cross-reactive neutralizing responses were rare after a single dose. At the peak of response to the second vaccine dose, all individuals had responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6 months after the primary series of the mRNA-1273 vaccine. Across all assays, B.1.351 had the lowest antibody recognition. These data complement ongoing studies to inform the potential need for additional boost vaccinations.
free
free
free
Science 2021 ; 373 (6561): 1372-1377
