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10.3389/fimmu.2021.698193 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.698193 34381451!8350391!34381451     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 698193 Nephropedia Template TP {{tp|p=34381451|t=2021. Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity |pdf=|usr=}}{{34381451}} gab.com Text Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34381451 #FOAvip HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding grooves did not predict COVID-19 severity. Further, we did not observe a heterozygote advantage or a benefit from HLA diplotypes with more divergent physicochemical peptide-binding properties. Finally, numbers of in silico predicted viral T-cell epitopes did not correlate with the severity of SARS-CoV-2 infections. These findings suggest that the HLA genotype is no major factor determining COVID-19 severity. Moreover, our data suggest that the spike glycoprotein alone may allow for abundant T-cell epitopes to mount robust T-cell responses not limited by the HLA genotype. Twit Text FOAVip Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34381451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34381451 #FOAvip English Wikipedia <ref>{{Cite pmid|34381451}}</ref> Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity #MMPMID34381451 Schetelig J; Heidenreich F; Baldauf H; Trost S; Falk B; Hossbach C; Real R; Roers A; Lindemann D; Dalpke A; Kolditz M; de With K; Bornhauser M; Bonifacio EE; Rucker-Braun E; Lange V; Markert J; Barth R; Hofmann JA; Sauter J; Bernas SN; Schmidt AH Front Immunol 2021[]; 12 (ä): 698193 PMID34381451show ga HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding grooves did not predict COVID-19 severity. Further, we did not observe a heterozygote advantage or a benefit from HLA diplotypes with more divergent physicochemical peptide-binding properties. Finally, numbers of in silico predicted viral T-cell epitopes did not correlate with the severity of SARS-CoV-2 infections. These findings suggest that the HLA genotype is no major factor determining COVID-19 severity. Moreover, our data suggest that the spike glycoprotein alone may allow for abundant T-cell epitopes to mount robust T-cell responses not limited by the HLA genotype. |Adult[MESH] |Computer Simulation[MESH] |Coronavirus Infections/*genetics[MESH] |Cross-Sectional Studies[MESH] |Epitopes, T-Lymphocyte/genetics/immunology[MESH] |Female[MESH] |Genotype[MESH] |Histocompatibility Antigens Class I/genetics/*immunology[MESH] |Histocompatibility Antigens Class II/genetics/*immunology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2[MESH]Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Whi(epmc).pdf DeepDyve Pubget Overpricing