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10.1038/s41467-021-24981-1 http://scihub22266oqcxt.onion/10.1038/s41467-021-24981-1 34381049!8357784!34381049     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4854 Nephropedia Template TP {{tp|p=34381049|t=2021. Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children |pdf=|usr=}}{{34381049}} gab.com Text Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34381049 #FOAvip Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, the genes, pathways and cell types causal to this new disease remain unknown. Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expression module annotated to CD56(dim)CD57(+) natural killer (NK) cells and exhausted CD8(+) T cells. A similar transcriptome signature is replicated in an independent cohort of Kawasaki disease (KD), the related condition after which MIS-C was initially named. Probing a probabilistic causal network previously constructed from over 1,000 blood transcriptomes both validates the structure of this module and reveals nine key regulators, including TBX21, a central coordinator of exhausted CD8(+) T cell differentiation. Together, this unbiased, transcriptome-wide survey implicates downregulation of NK cells and cytotoxic T cell exhaustion in the pathogenesis of MIS-C. Twit Text FOAVip Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34381049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34381049 #FOAvip English Wikipedia <ref>{{Cite pmid|34381049}}</ref> Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children #MMPMID34381049 Beckmann ND; Comella PH; Cheng E; Lepow L; Beckmann AG; Tyler SR; Mouskas K; Simons NW; Hoffman GE; Francoeur NJ; Del Valle DM; Kang G; Do A; Moya E; Wilkins L; Le Berichel J; Chang C; Marvin R; Calorossi S; Lansky A; Walker L; Yi N; Yu A; Chung J; Hartnett M; Eaton M; Hatem S; Jamal H; Akyatan A; Tabachnikova A; Liharska LE; Cotter L; Fennessy B; Vaid A; Barturen G; Shah H; Wang YC; Sridhar SH; Soto J; Bose S; Madrid K; Ellis E; Merzier E; Vlachos K; Fishman N; Tin M; Smith M; Xie H; Patel M; Nie K; Argueta K; Harris J; Karekar N; Batchelor C; Lacunza J; Yishak M; Tuballes K; Scott I; Kumar A; Jaladanki S; Agashe C; Thompson R; Clark E; Losic B; Peters L; Roussos P; Zhu J; Wang W; Kasarskis A; Glicksberg BS; Nadkarni G; Bogunovic D; Elaiho C; Gangadharan S; Ofori-Amanfo G; Alesso-Carra K; Onel K; Wilson KM; Argmann C; Bunyavanich S; Alarcon-Riquelme ME; Marron TU; Rahman A; Kim-Schulze S; Gnjatic S; Gelb BD; Merad M; Sebra R; Schadt EE; Charney AW Nat Commun 2021[Aug]; 12 (1): 4854 PMID34381049show ga Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, the genes, pathways and cell types causal to this new disease remain unknown. Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expression module annotated to CD56(dim)CD57(+) natural killer (NK) cells and exhausted CD8(+) T cells. A similar transcriptome signature is replicated in an independent cohort of Kawasaki disease (KD), the related condition after which MIS-C was initially named. Probing a probabilistic causal network previously constructed from over 1,000 blood transcriptomes both validates the structure of this module and reveals nine key regulators, including TBX21, a central coordinator of exhausted CD8(+) T cell differentiation. Together, this unbiased, transcriptome-wide survey implicates downregulation of NK cells and cytotoxic T cell exhaustion in the pathogenesis of MIS-C. |Adolescent[MESH] |CD56 Antigen/metabolism[MESH] |CD57 Antigens/metabolism[MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism[MESH] |COVID-19/genetics/*immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Down-Regulation[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Killer Cells, Natural/immunology/metabolism[MESH] |Male[MESH] |Mucocutaneous Lymph Node Syndrome/genetics/immunology[MESH] |SARS-CoV-2/pathogenicity[MESH] |Systemic Inflammatory Response Syndrome/genetics/*immunology[MESH] |Transcriptome/*immunology[MESH]Downregulation of exhausted cytotoxic T cells in gene expression netwo(epmc).pdf DeepDyve Pubget Overpricing