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10.1038/s41467-021-25030-7 http://scihub22266oqcxt.onion/10.1038/s41467-021-25030-7 34381043!8357947!34381043     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4869 Nephropedia Template TP {{tp|p=34381043|t=2021. Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19 |pdf=|usr=}}{{34381043}} gab.com Text Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34381043 #FOAvip In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly involving endothelial cells, remain ill-defined. Using Syrian hamsters as a model for moderate COVID-19, we conduct a detailed longitudinal analysis of systemic and pulmonary cellular responses, and corroborate it with datasets from COVID-19 patients. Monocyte-derived macrophages in lungs exert the earliest and strongest transcriptional response to infection, including induction of pro-inflammatory genes, while epithelial cells show weak alterations. Without evidence for productive infection, endothelial cells react, depending on cell subtypes, by strong and early expression of anti-viral, pro-inflammatory, and T cell recruiting genes. Recruitment of cytotoxic T cells as well as emergence of IgM antibodies precede viral clearance at day 5 post infection. Investigating SARS-CoV-2 infected Syrian hamsters thus identifies cell type-specific effector functions, providing detailed insights into pathomechanisms of COVID-19 and informing therapeutic strategies. Twit Text FOAVip Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34381043 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34381043 #FOAvip English Wikipedia <ref>{{Cite pmid|34381043}}</ref> Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19 #MMPMID34381043 Nouailles G; Wyler E; Pennitz P; Postmus D; Vladimirova D; Kazmierski J; Pott F; Dietert K; Muelleder M; Farztdinov V; Obermayer B; Wienhold SM; Andreotti S; Hoefler T; Sawitzki B; Drosten C; Sander LE; Suttorp N; Ralser M; Beule D; Gruber AD; Goffinet C; Landthaler M; Trimpert J; Witzenrath M Nat Commun 2021[Aug]; 12 (1): 4869 PMID34381043show ga In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly involving endothelial cells, remain ill-defined. Using Syrian hamsters as a model for moderate COVID-19, we conduct a detailed longitudinal analysis of systemic and pulmonary cellular responses, and corroborate it with datasets from COVID-19 patients. Monocyte-derived macrophages in lungs exert the earliest and strongest transcriptional response to infection, including induction of pro-inflammatory genes, while epithelial cells show weak alterations. Without evidence for productive infection, endothelial cells react, depending on cell subtypes, by strong and early expression of anti-viral, pro-inflammatory, and T cell recruiting genes. Recruitment of cytotoxic T cells as well as emergence of IgM antibodies precede viral clearance at day 5 post infection. Investigating SARS-CoV-2 infected Syrian hamsters thus identifies cell type-specific effector functions, providing detailed insights into pathomechanisms of COVID-19 and informing therapeutic strategies. |*Disease Models, Animal[MESH] |Alveolar Epithelial Cells/immunology[MESH] |Animals[MESH] |COVID-19/*immunology[MESH] |Cricetinae[MESH] |Cytokines/genetics/immunology[MESH] |Endothelial Cells/immunology[MESH] |Humans[MESH] |Immunoglobulin M/immunology[MESH] |Inflammation[MESH] |Lung/immunology[MESH] |Macrophages/immunology[MESH] |Mesocricetus[MESH] |Monocytes/immunology[MESH] |SARS-CoV-2/immunology[MESH] |Signal Transduction[MESH] |T-Lymphocytes, Cytotoxic/immunology[MESH]Temporal omics analysis in Syrian hamsters unravel cellular effector r(epmc).pdf DeepDyve Pubget Overpricing