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10.1038/s41467-021-25113-5 http://scihub22266oqcxt.onion/10.1038/s41467-021-25113-5 34381030!8357797!34381030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34381030&cmd=llinks): Failed to open stream: HTTP request failed! 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Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors |pdf=|usr=}}{{34381030}} gab.com Text Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34381030 #FOAvip Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, we hypothesize that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to approximately 28,000 patients from the Expanded Access to Convalescent Plasma program (ClinicalTrials.gov number: NCT04338360) support this hypothesis. This work has implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge. Twit Text FOAVip Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34381030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34381030 #FOAvip English Wikipedia <ref>{{Cite pmid|34381030}}</ref> Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors #MMPMID34381030 Kunze KL; Johnson PW; van Helmond N; Senefeld JW; Petersen MM; Klassen SA; Wiggins CC; Klompas AM; Bruno KA; Mills JR; Theel ES; Buras MR; Golafshar MA; Sexton MA; Diaz Soto JC; Baker SE; Shepherd JRA; Verdun NC; Marks P; Paneth NS; Fairweather D; Wright RS; van Buskirk CM; Winters JL; Stubbs JR; Senese KA; Pletsch MC; Buchholtz ZA; Rea RF; Herasevich V; Whelan ER; Clayburn AJ; Larson KF; Ripoll JG; Andersen KJ; Lesser ER; Vogt MNP; Dennis JJ; Regimbal RJ; Bauer PR; Blair JE; Casadevall A; Carter RE; Joyner MJ Nat Commun 2021[Aug]; 12 (1): 4864 PMID34381030show ga Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, we hypothesize that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to approximately 28,000 patients from the Expanded Access to Convalescent Plasma program (ClinicalTrials.gov number: NCT04338360) support this hypothesis. This work has implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Viral/immunology[MESH] |Antibody Specificity[MESH] |Antigenic Variation[MESH] |Blood Donors[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/mortality/*therapy[MESH] |Female[MESH] |Humans[MESH] |Immunization, Passive/mortality[MESH] |Male[MESH] |Middle Aged[MESH] |Plasma/*immunology[MESH] |SARS-CoV-2/genetics/immunology[MESH] |Treatment Outcome[MESH] |United States/epidemiology[MESH]Mortality in individuals treated with COVID-19 convalescent plasma var(epmc).pdf DeepDyve Pubget Overpricing