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10.1128/JCM.01138-21

http://scihub22266oqcxt.onion/10.1128/JCM.01138-21
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34379530!8525561!34379530
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suck abstract from ncbi


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pmid34379530      J+Clin+Microbiol 2021 ; 59 (11): e0113821
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  • The Fall in Antibody Response to SARS-CoV-2: a Longitudinal Study of Asymptomatic to Critically Ill Patients Up to 10 Months after Recovery #MMPMID34379530
  • Peghin M; De Martino M; Fabris M; Palese A; Visintini E; Graziano E; Gerussi V; Bontempo G; D'Aurizio F; Biasotto A; Sartor A; Pipan C; Marzinotto S; Curcio F; Bouza E; Isola M; Tascini C
  • J Clin Microbiol 2021[Oct]; 59 (11): e0113821 PMID34379530show ga
  • The aim of this study was to assess the long-term dynamics and factors associated with the serological response against the severe acute respiratory syndrome coronavirus 2 after primary infection. A prospective longitudinal study was conducted with monthly serological follow-up during the first 4 months, and then at 6, 8, and 10 months after the disease onset of all recovered adult in- and outpatients with coronavirus disease 2019 (COVID-19) attending Udine Hospital (Italy) during the first wave (from March to May 2020). A total of 546 individuals were included (289 female, mean age 53.1 years), mostly with mild COVID-19 (370, 68.3%). Patients were followed for a median of 302 days (interquartile range, 186 to 311). The overall seroconversion rate within 2 months was 32% for IgM and 90% for IgG. Seroreversion was observed in 90% of patients for IgM at 4 months and in 47% for IgG at 10 months. Older age, number of symptoms at acute onset, and severity of acute COVID-19 were all independent predictors of long-term immunity both for IgM (beta, linear regression coefficient, 1.10, P = 0.001; beta 5.15 P = 0.014; beta 43.84 P = 0.021, respectively) and for IgG (beta 1.43 P < 0.001; beta 10.46 P < 0.001; beta 46.79 P < 0.001, respectively), whereas the initial IgG peak was associated only with IgG duration (beta 1.12, P < 0.001). IgM antibodies disappeared at 4 months, and IgG antibodies declined in about half of patients 10 months after acute COVID-19. These effects varied depending on the intensity of the initial antibody response, age, and burden of acute COVID-19.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral[MESH]
  • |Antibody Formation[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin M[MESH]
  • |Longitudinal Studies[MESH]
  • |Middle Aged[MESH]


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