Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1021/acs.jproteome.1c00215

http://scihub22266oqcxt.onion/10.1021/acs.jproteome.1c00215
suck pdf from google scholar
34379420!8370121!34379420
unlimited free pdf from europmc34379420    free
PDF from PMC    free
html from PMC    free
PDF vom PMID34379420  :  Publisher

suck abstract from ncbi

pmid34379420
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • A Multi-omics Longitudinal Study Reveals Alteration of the Leukocyte Activation Pathway in COVID-19 Patients #MMPMID34379420
  • Suvarna K; Salkar A; Palanivel V; Bankar R; Banerjee N; Gayathri J Pai M; Srivastava A; Singh A; Khatri H; Agrawal S; Shrivastav O; Shastri J; Srivastava S
  • J Proteome Res 2021[Oct]; 20 (10): 4667-4680 PMID34379420show ga
  • Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated immune response are yet to be elucidated. We performed a mass-spectrometry-based proteomic and metabolomic analysis of COVID-19 plasma samples collected at two time points. Using Orbitrap Fusion LC-MS/MS-based label-free proteomic analysis, we identified around 10 significant proteins, 32 significant peptides, and 5 metabolites that were dysregulated at the severe time points. Few of these proteins identified by quantitative proteomics were validated using the multiple reaction monitoring (MRM) assay. Integrated pathway analysis using distinct proteomic and metabolomic signatures revealed alterations in complement and coagulation cascade, platelet aggregation, myeloid leukocyte activation pathway, and arginine metabolism. Further, we highlight the role of leukocyte activation and arginine metabolism in COVID-19 pathogenesis and targeting these pathways for COVID-19 therapeutics.
  • |*COVID-19[MESH]
  • |*Proteomics[MESH]
  • |Chromatography, Liquid[MESH]
  • |Humans[MESH]
  • |Leukocytes[MESH]
  • |Longitudinal Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Tandem Mass Spectrometry[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    4667 10.20 2021